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Pot1 protection of telomeres 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500054, updated on 2-Oct-2018

Summary

Official Symbol
Pot1provided by RGD
Official Full Name
protection of telomeres 1provided by RGD
Primary source
RGD:1562696
See related
Ensembl:ENSRNOG00000019986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pot1a
Expression
Biased expression in Thymus (RPKM 109.1), Spleen (RPKM 80.3) and 9 other tissues See more
Orthologs

Genomic context

See Pot1 in Genome Data Viewer
Location:
4q22
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51888632..51946764, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (51664672..51722749, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene thymosin beta-10 pseudogene Neighboring gene G protein-coupled receptor 37 Neighboring gene uncharacterized LOC108350678 Neighboring gene hyaluronoglucosaminidase 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
8-hydroxy-2'-deoxyguanosine DNA binding ISO
Inferred from Sequence Orthology
more info
 
DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
 
G-rich single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomerase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
telomeric D-loop binding ISO
Inferred from Sequence Orthology
more info
 
telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
NOT telomeric G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
chromosome organization ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
telomere assembly ISO
Inferred from Sequence Orthology
more info
 
telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere capping ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
telomeric D-loop disassembly ISO
Inferred from Sequence Orthology
more info
 
NOT telomeric loop formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear telomere cap complex ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
shelterin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protection of telomeres protein 1
Names
protection of telomeres 1 homolog
protection of telomeres 1A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024322.1NP_001019493.1  protection of telomeres protein 1

    See identical proteins and their annotated locations for NP_001019493.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085834
    UniProtKB/TrEMBL
    Q5U2W8
    Related
    ENSRNOP00000057203.2, ENSRNOT00000060459.3
    Conserved Domains (2) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:161279
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    51888632..51946764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762811.1XP_008761033.1  protection of telomeres protein 1 isoform X3

    Conserved Domains (2) summary
    smart00976
    Location:182
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:102220
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...
  2. XM_017592783.1XP_017448272.1  protection of telomeres protein 1 isoform X2

  3. XM_006236160.2XP_006236222.1  protection of telomeres protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006236222.1

    UniProtKB/TrEMBL
    A0A0G2JX31
    Related
    ENSRNOP00000070115.1, ENSRNOT00000079130.1
    Conserved Domains (2) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:161279
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...
  4. XM_006236161.2XP_006236223.1  protection of telomeres protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006236223.1

    UniProtKB/TrEMBL
    A0A0G2JX31
    Conserved Domains (2) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:161279
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...
  5. XM_017592782.1XP_017448271.1  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX31
    Conserved Domains (2) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:161279
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...

RNA

  1. XR_353175.2 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    49343691..49398232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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