Format

Send to:

Choose Destination

Pot1 protection of telomeres 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500054, updated on 5-Jan-2022

Summary

Official Symbol
Pot1provided by RGD
Official Full Name
protection of telomeres 1provided by RGD
Primary source
RGD:1562696
See related
Ensembl:ENSRNOG00000019986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pot1a
Summary
Predicted to enable DEAD/H-box RNA helicase binding activity; DNA binding activity; and telomerase inhibitor activity. Predicted to be involved in several processes, including establishment of protein localization to telomere; regulation of DNA metabolic process; and telomere organization. Predicted to act upstream of or within chromosome organization. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in familial melanoma and high grade glioma. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 109.1), Spleen (RPKM 80.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pot1 in Genome Data Viewer
Location:
4q22
Exon count:
20
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (54205330..54263137, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51888632..51946764, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene similar to suppressor of variegation 3-9 homolog 2 Neighboring gene G protein-coupled receptor 37 Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC120102246 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 8-hydroxy-2'-deoxyguanosine DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
 
enables G-rich single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables telomerase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables telomeric D-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables telomeric G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in telomeric D-loop disassembly ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in telomeric loop formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear telomere cap complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of shelterin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protection of telomeres protein 1
Names
protection of telomeres 1 homolog
protection of telomeres 1A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395151.1NP_001382080.1  protection of telomeres protein 1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000141
    Conserved Domains (3) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:348634
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153294
    POT1PC; ssDNA-binding domain of telomere protection protein
  2. NM_001395152.1NP_001382081.1  protection of telomeres protein 1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000141
    Conserved Domains (3) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:348634
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153294
    POT1PC; ssDNA-binding domain of telomere protection protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    54205330..54263137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762811.2XP_008761033.1  protection of telomeres protein 1 isoform X2

    Conserved Domains (2) summary
    smart00976
    Location:182
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:102220
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...
  2. XM_006236160.3XP_006236222.1  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX31
    Conserved Domains (3) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:348634
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153294
    POT1PC; ssDNA-binding domain of telomere protection protein
  3. XM_006236161.3XP_006236223.1  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX31
    Related
    ENSRNOP00000070115.1, ENSRNOT00000079130.2
    Conserved Domains (3) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:348634
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153294
    POT1PC; ssDNA-binding domain of telomere protection protein
  4. XM_039108102.1XP_038964030.1  protection of telomeres protein 1 isoform X1

    Conserved Domains (3) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:348634
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153294
    POT1PC; ssDNA-binding domain of telomere protection protein
  5. XM_017592782.2XP_017448271.1  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX31
    Conserved Domains (3) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:348634
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153294
    POT1PC; ssDNA-binding domain of telomere protection protein

RNA

  1. XR_005503291.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024322.2: Suppressed sequence

    Description
    NM_001024322.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center