Apcdd1l APC down-regulated 1 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apcdd1lprovided by RGD
Official Full Name: APC down-regulated 1 likeprovided by RGD
Primary source: RGD:1562045
See related: Ensembl:ENSRNOG00000028440 AllianceGenome:RGD:1562045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Wnt-protein binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Orthologous to human APCDD1L (APC down-regulated 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Kidney (RPKM 38.0), Spleen (RPKM 9.7) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 3q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (183000504..183076628, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (162587484..162658362, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (171879728..171958155, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH39400 (e-PCR)
- UniSTS:88876

D3Mco76 (e-PCR)
- UniSTS:517983

D3Rat2 (e-PCR)
- UniSTS:118761

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein APCDD1-like

Names: adenomatosis polyposis coli down-regulated 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430739.1 → NP_001417668.1 protein APCDD1-like isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6KL15, F7EL46, Q66HE0
NM_001430740.1 → NP_001417669.1 protein APCDD1-like isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

183000504..183076628 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285326.1 → XP_063141396.1

Related

ENSRNOP00000032411.3, ENSRNOT00000036546.6
XM_006235711.5 → XP_006235773.1

Conserved Domains (1) summary

pfam14921
Location:32 → 267

APCDDC; Adenomatosis polyposis coli down-regulated 1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024315.1: Suppressed sequence

Description

NM_001024315.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: APCDD1L (GeneID:164284).