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Rad51 RAD51 recombinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 499870, updated on 9-Oct-2018

Summary

Official Symbol
Rad51provided by RGD
Official Full Name
RAD51 recombinaseprovided by RGD
Primary source
RGD:1563603
See related
Ensembl:ENSRNOG00000037302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563603
Expression
Biased expression in Thymus (RPKM 112.8), Spleen (RPKM 60.0) and 9 other tissues See more
Orthologs

Genomic context

See Rad51 in Genome Data Viewer
Location:
3q35
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110918240..110942920)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (117468402..117493566)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene kinetochore scaffold 1 Neighboring gene regulator of microtubule dynamics 3 Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
recombinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded DNA-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA recombinase assembly ISO
Inferred from Sequence Orthology
more info
 
DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to alkaloid IEA
Inferred from Electronic Annotation
more info
 
cellular response to alkaloid ISO
Inferred from Sequence Orthology
more info
 
cellular response to camptothecin ISO
Inferred from Sequence Orthology
more info
 
cellular response to cisplatin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydroxyurea IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome organization involved in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via homologous recombination IEP
Inferred from Expression Pattern
more info
PubMed 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
meiosis I IEP
Inferred from Expression Pattern
more info
PubMed 
meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic recombination-dependent replication fork processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA ligation ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
replication fork processing ISO
Inferred from Sequence Orthology
more info
 
replication-born double-strand break repair via sister chromatid exchange IEA
Inferred from Electronic Annotation
more info
 
replication-born double-strand break repair via sister chromatid exchange ISO
Inferred from Sequence Orthology
more info
 
response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucoside IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance via telomere lengthening IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
telomere organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
PML body ISO
Inferred from Sequence Orthology
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
lateral element IEA
Inferred from Electronic Annotation
more info
 
lateral element ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA repair protein RAD51 homolog 1
Names
RAD51 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109204.1NP_001102674.1  DNA repair protein RAD51 homolog 1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    B5DF04
    Related
    ENSRNOP00000053270.2, ENSRNOT00000056432.2
    Conserved Domains (3) summary
    cd01123
    Location:102335
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
    pfam14520
    Location:3280
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    110918240..110942920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234784.3XP_006234846.1  DNA repair protein RAD51 homolog 1 isoform X1

    UniProtKB/TrEMBL
    B5DF04
    Conserved Domains (3) summary
    cd01123
    Location:102335
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51
    pfam14520
    Location:3280
    HHH_5; Helix-hairpin-helix domain

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    105013953..105038371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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