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ORC1 origin recognition complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 4998, updated on 7-Jun-2020

Summary

Official Symbol
ORC1provided by HGNC
Official Full Name
origin recognition complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:8487
See related
Ensembl:ENSG00000085840 MIM:601902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC1L; PARC1; HSORC1
Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in bone marrow (RPKM 7.3), lymph node (RPKM 2.5) and 10 other tissues See more
Orthologs

Genomic context

See ORC1 in Genome Data Viewer
Location:
1p32.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (52372829..52404471, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52838501..52870143, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 9 Neighboring gene phospholipase A2 group XIIA pseudogene 1 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene pre-mRNA processing factor 38A Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC105378723

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nuclear chromosome, telomeric region HDA PubMed 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
origin recognition complex subunit 1
Names
origin recognition complex, subunit 1 homolog
replication control protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028251.1 RefSeqGene

    Range
    5049..36643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190818.1NP_001177747.1  origin recognition complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_001177747.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, resulting in 3 nt fewer than variant 1. Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    BC011539, BP280383, U43416
    Consensus CDS
    CCDS566.1
    UniProtKB/Swiss-Prot
    Q13415
    UniProtKB/TrEMBL
    Q96F82
    Related
    ENSP00000360621.1, ENST00000371566.1
    Conserved Domains (5) summary
    cd04719
    Location:44170
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    pfam09079
    Location:778851
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:504554
    AAA_16; AAA ATPase domain
    pfam15091
    Location:394519
    DUF4554; Domain of unknown function (DUF4554)
    cl21455
    Location:530675
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001190819.1NP_001177748.1  origin recognition complex subunit 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the CDS, resulting in 15 nt fewer than variant 1. The resulting isoform (2) lacks internal 5 aa, as compared to isoform 1.
    Source sequence(s)
    AK303420, DB156841, U43416
    UniProtKB/Swiss-Prot
    Q13415
    UniProtKB/TrEMBL
    B7Z8H0
    Conserved Domains (4) summary
    cd04719
    Location:44170
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    pfam09079
    Location:773846
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:499549
    AAA_16; AAA ATPase domain
    cl21455
    Location:525670
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_004153.4NP_004144.2  origin recognition complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_004144.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    U40152, U43416
    Consensus CDS
    CCDS566.1
    UniProtKB/Swiss-Prot
    Q13415
    Related
    ENSP00000360623.3, ENST00000371568.8
    Conserved Domains (5) summary
    cd04719
    Location:44170
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    pfam09079
    Location:778851
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:504554
    AAA_16; AAA ATPase domain
    pfam15091
    Location:394519
    DUF4554; Domain of unknown function (DUF4554)
    cl21455
    Location:530675
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    52372829..52404471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001388.2XP_016856877.1  origin recognition complex subunit 1 isoform X1

  2. XM_017001389.2XP_016856878.1  origin recognition complex subunit 1 isoform X2

  3. XM_011541527.3XP_011539829.1  origin recognition complex subunit 1 isoform X3

    Conserved Domains (4) summary
    pfam09079
    Location:418491
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:144194
    AAA_16; AAA ATPase domain
    pfam15091
    Location:34159
    DUF4554; Domain of unknown function (DUF4554)
    cl21455
    Location:170315
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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