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Slf2 SMC5/6 complex localization factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499360, updated on 16-Jun-2026
Official Symbol
Slf2provided by RGD
Official Full Name
SMC5/6 complex localization factor 2provided by RGD
Primary source
RGD:1560300
See related
Ensembl:ENSRNOG00000014482 AllianceGenome:RGD:1560300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam178a; RGD1560300
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Predicted to be located in PML body and chromatin. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SLF2 (SMC5-SMC6 complex localization factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 130.9), Brain (RPKM 115.7) and 9 other tissues See more
Orthologs
all
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See Slf2 in Genome Data Viewer
Location:
1q54
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (253731979..253794577)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (243782786..243845418)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (264670836..264733465)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100041 Neighboring gene 5S ribosomal RNA Neighboring gene RNA, U6 small nuclear 588 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene semaphorin 4G Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. Alabert C, et al. Nat Cell Biol, 2014 Mar. PMID 24561620, Free PMC Article
  2. DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Räschle M, et al. Science, 2015 May 1. PMID 25931565, Free PMC Article
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to site of double-strand break IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
SMC5-SMC6 complex localization factor protein 2
Names
SMC5-SMC6 complex localization factor 2
family with sequence similarity 178, member A
protein FAM178A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134612.2 → NP_001128084.1  SMC5-SMC6 complex localization factor protein 2

    See identical proteins and their annotated locations for NP_001128084.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZF72
    Related
    ENSRNOP00000031171.4, ENSRNOT00000034814.8
    Conserved Domains (1) summary
    pfam14816
    Location:652 → 1018
    FAM178; Family of unknown function, FAM178

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    253731979..253794577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589590.3 → XP_017445079.1  SMC5-SMC6 complex localization factor protein 2 isoform X3

  2. XM_039088080.2 → XP_038944008.1  SMC5-SMC6 complex localization factor protein 2 isoform X4

    Conserved Domains (1) summary
    pfam14816
    Location:652 → 1003
    FAM178; Family of unknown function, FAM178

  3. XM_063271766.1 → XP_063127836.1  SMC5-SMC6 complex localization factor protein 2 isoform X5

  4. XM_006231550.5 → XP_006231612.1  SMC5-SMC6 complex localization factor protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUU2
    Related
    ENSRNOP00000069230.3, ENSRNOT00000082412.3
    Conserved Domains (1) summary
    pfam14816
    Location:652 → 1019
    FAM178; Family of unknown function, FAM178

  5. XM_006231551.5 → XP_006231613.1  SMC5-SMC6 complex localization factor protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JUU2
    Conserved Domains (1) summary
    pfam14816
    Location:652 → 1018
    FAM178; Family of unknown function, FAM178

  6. XM_039088085.2 → XP_038944013.1  SMC5-SMC6 complex localization factor protein 2 isoform X6

    Conserved Domains (1) summary
    pfam14816
    Location:7 → 377
    FAM178; Family of unknown function, FAM178
Nucleotide Protein Strain
Heading Accession and Version

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