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Selenov selenoprotein V [ Rattus norvegicus (Norway rat) ]

Gene ID: 499113, updated on 10-Oct-2019

Summary

Official Symbol
Selenovprovided by RGD
Official Full Name
selenoprotein Vprovided by RGD
Primary source
RGD:1562943
See related
Ensembl:ENSRNOG00000051208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Selv; RGD1562943
Summary
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2017]
Expression
Restricted expression toward (RPKM 118.4) See more
Orthologs

Genomic context

See Selenov in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85496940..85504189)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (77950491..77957778, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (86708083..86715303)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene delta like canonical Notch ligand 3 Neighboring gene EP300 interacting inhibitor of differentiation 2B Neighboring gene EP300 interacting inhibitor of differentiation 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Selenium metabolism Selenoproteins, organism-specific biosystem (from WikiPathways)
    Selenium metabolism Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...

General gene information

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
response to selenium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166396.1NP_001159868.1  selenoprotein V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenoprotein.
    Source sequence(s)
    AABR07002795, BC158767
    UniProtKB/TrEMBL
    B0BNC5
    Related
    ENSRNOP00000068219.1, ENSRNOT00000076809.2
    Conserved Domains (1) summary
    TIGR02174
    Location:245318
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RNA

  1. NR_146923.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AABR07002795, BC158767
  2. NR_146924.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site at the 5' terminal exon, and lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AABR07002795, BC158767

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    85496940..85504189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    77950491..77957778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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