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Ppp1r12c protein phosphatase 1, regulatory subunit 12C [ Rattus norvegicus (Norway rat) ]

Gene ID: 499076, updated on 5-Jul-2025
Official Symbol
Ppp1r12cprovided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 12Cprovided by RGD
Primary source
RGD:1584883
See related
Ensembl:ENSRNOG00000053828 AllianceGenome:RGD:1584883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in neuron projection morphogenesis. Predicted to be located in stress fiber. Predicted to be active in cytoplasm. Orthologous to human PPP1R12C (protein phosphatase 1 regulatory subunit 12C). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 212.5), Heart (RPKM 208.9) and 9 other tissues See more
Orthologs
human mouse all
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See Ppp1r12c in Genome Data Viewer
Location:
1q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78362900..78385873)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69320240..69343200)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72903139..72926108)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin I3, cardiac type Neighboring gene troponin T1, slow skeletal type Neighboring gene EPS8 signaling adaptor L1 Neighboring gene retinol dehydrogenase 13

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein phosphatase 1 regulatory subunit 12C
Names
protein phosphatase 1, regulatory (inhibitor) subunit 12C

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191946.2 → NP_001178875.2  protein phosphatase 1 regulatory subunit 12C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K4R1, A6KNL5
    Related
    ENSRNOP00000073139.1, ENSRNOT00000086122.3
    Conserved Domains (5) summary
    cd00204
    Location:99 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:109 → 261
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:264 → 312
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:685 → 783
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:104 → 135
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78362900..78385873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758961.3 → XP_008757183.1  protein phosphatase 1 regulatory subunit 12C isoform X1

    UniProtKB/TrEMBL
    A6KNL5
    Conserved Domains (5) summary
    cd00204
    Location:99 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:109 → 261
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:264 → 312
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:684 → 782
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:104 → 135
    ANK; ANK repeat [structural motif]

  2. XM_017589553.3 → XP_017445042.1  protein phosphatase 1 regulatory subunit 12C isoform X2

  3. XM_063270835.1 → XP_063126905.1  protein phosphatase 1 regulatory subunit 12C isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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