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Zdhhc11 zDHHC palmitoyltransferase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499000, updated on 6-Jul-2026
Official Symbol
Zdhhc11provided by RGD
Official Full Name
zDHHC palmitoyltransferase 11provided by RGD
Primary source
RGD:1564281
See related
Ensembl:ENSRNOG00000039743 AllianceGenome:RGD:1564281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf399; Zdhhc20
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity and signaling adaptor activity. Predicted to be involved in antiviral innate immune response; positive regulation of defense response to virus by host; and protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to several human genes including ZDHHC11 (zinc finger DHHC-type containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward (RPKM 19.6) See more
Orthologs
all
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See Zdhhc11 in Genome Data Viewer
Location:
1p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31124900..31156075, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29296334..29327227, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 72 Neighboring gene tubulin polymerization promoting protein Neighboring gene uncharacterized LOC134484978 Neighboring gene bromodomain containing 9 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene thyroid hormone receptor interactor 13

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. Liu Y, et al. Cell Mol Immunol, 2018 Oct. PMID 29429998, Free PMC Article
  2. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article
  3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
probable palmitoyltransferase ZDHHC11
Names
DHHC-containing protein 10
membrane-associated DHHC11 zinc finger protein
zinc finger, DHHC domain containing 11
zinc finger, DHHC-type containing 11
NP_001034431.2
NP_001406430.1
XP_038942712.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039342.3 → NP_001034431.2  probable palmitoyltransferase ZDHHC11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ALH7
    Related
    ENSRNOP00000094386.2, ENSRNOT00000117184.2
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 282
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_001419501.1 → NP_001406430.1  probable palmitoyltransferase ZDHHC11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ALH7

  3. NM_001446759.1 → NP_001433688.1  probable palmitoyltransferase ZDHHC11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ALH7, F1M6X9

  4. NM_001446760.1 → NP_001433689.1  probable palmitoyltransferase ZDHHC11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    31124900..31156075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086784.2 → XP_038942712.1  

    Related
    ENSRNOP00000057691.5, ENSRNOT00000060971.5
    Conserved Domains (1) summary
    pfam01529
    Location:123 → 294
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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