Rspo3 R-spondin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rspo3provided by RGD
Official Full Name: R-spondin 3provided by RGD
Primary source: RGD:1563246
See related: Ensembl:ENSRNOG00000011568 AllianceGenome:RGD:1563246
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563246
Summary: Predicted to enable frizzled binding activity and heparin binding activity. Predicted to be involved in blood vessel remodeling; positive regulation of Wnt signaling pathway; and sprouting angiogenesis. Predicted to act upstream of or within angiogenesis and branching involved in labyrinthine layer morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human RSPO3 (R-spondin 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Uterus (RPKM 75.1), Adrenal (RPKM 34.9) and 4 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (30112529..30197267)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (28283914..28368661)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circuits in the brain to regulate energy homeostasis.
Title: LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Got34 (e-PCR)
- UniSTS:115752

BM384382 (e-PCR)
- UniSTS:260965

BE111437 (e-PCR)
- UniSTS:245676

General protein information

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Preferred Names: R-spondin-3

Names: R-spondin 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100990.1 → NP_001094460.1 R-spondin-3 precursor

See identical proteins and their annotated locations for NP_001094460.1

Status: PROVISIONAL

Source sequence(s)

EU030376

UniProtKB/TrEMBL

A0ABK0LF76, A7LKE6

Related

ENSRNOP00000101906.1, ENSRNOT00000155119.1

Conserved Domains (3) summary

smart00209
Location:151 → 202

TSP1; Thrombospondin type 1 repeats

cd00064
Location:97 → 143

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam15913
Location:42 → 144

Furin-like_2; Furin-like repeat, cysteine-rich