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OPRM1 opioid receptor mu 1 [ Homo sapiens (human) ]

Gene ID: 4988, updated on 12-Aug-2018

Summary

Official Symbol
OPRM1provided by HGNC
Official Full Name
opioid receptor mu 1provided by HGNC
Primary source
HGNC:HGNC:8156
See related
Ensembl:ENSG00000112038 MIM:600018; Vega:OTTHUMG00000015870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
Summary
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See OPRM1 in Genome Data Viewer
Location:
6q25.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (154010496..154246867)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154331631..154568001)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 896, pseudogene Neighboring gene high mobility group box 3 pseudogene 19 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene uncharacterized LOC105378067 Neighboring gene CNKSR family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cyclic d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), mu-opioid receptor-selective antagonist, significantly delay the febrile response induced by HIV-1 gp120, suggesting that mu-opioid receptors can regulate gp120-induced fever PubMed
env HIV-1 gp120 induces desensitization of a mu-opioid-receptor-mediated response in brain periaqueductal gray neurons PubMed
env HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR PubMed
env HIV-1 gp120 upregulates mu opiate receptor expression in human vascular endothelium; in contrast, morphine decreases mu opioid receptor expression PubMed
Tat tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
    Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Estrogen signaling pathway, conserved biosystem (from KEGG)
    Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G-protein activation, organism-specific biosystem (from REACTOME)
    G-protein activation, organism-specific biosystemReceptor activated heterotrimeric G proteins consist of the Galpha and the tightly associated Gbeta-gamma subunits. When a ligand binds to a G protein-coupled receptor, it stabilises a conformation ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL4-mediated signaling events, organism-specific biosystem
    IL4-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Opioid Signalling, organism-specific biosystem (from REACTOME)
    Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
beta-endorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-endorphin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
filamin binding IEA
Inferred from Electronic Annotation
more info
 
morphine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to growth factor IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to radiation IEA
Inferred from Electronic Annotation
more info
 
sensory perception NAS
Non-traceable Author Statement
more info
PubMed 
sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
spine apparatus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mu-type opioid receptor
Names
mu opiate receptor
mu opioid receptor hMOR-1a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021208.2 RefSeqGene

    Range
    33911..241367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000914.4NP_000905.3  mu-type opioid receptor isoform MOR-1

    See identical proteins and their annotated locations for NP_000905.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1) has a shorter N-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
    Source sequence(s)
    AL132774, FJ041291
    Consensus CDS
    CCDS55070.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000328264.7, OTTHUMP00000017463, ENST00000330432.11, OTTHUMT00000042786
    Conserved Domains (1) summary
    cd15090
    Location:71349
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001008503.2NP_001008503.2  mu-type opioid receptor isoform MOR-1O

    See identical proteins and their annotated locations for NP_001008503.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1O) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1O) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AY036623, FJ041291
    Consensus CDS
    CCDS43517.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000338381.4, OTTHUMP00000225133, ENST00000337049.8, OTTHUMT00000375913
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  3. NM_001008504.3NP_001008504.2  mu-type opioid receptor isoform MOR-1A

    See identical proteins and their annotated locations for NP_001008504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1A) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1A) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
    Source sequence(s)
    AY309001, AY364890, FJ041291
    Consensus CDS
    CCDS47508.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000411903.2, OTTHUMP00000017464, ENST00000428397.6, OTTHUMT00000042787
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  4. NM_001008505.2NP_001008505.2  mu-type opioid receptor isoform MOR-1X

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1X), also known as MOR-1R, represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1X) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL136444, AY036622, FJ041291
    Consensus CDS
    CCDS43518.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000229768.5, OTTHUMP00000225139, ENST00000229768.9, OTTHUMT00000375933
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  5. NM_001145279.3NP_001138751.1  mu-type opioid receptor isoform MOR-1i

    See identical proteins and their annotated locations for NP_001138751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1i) encodes the longest isoform (MOR-1i). Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).
    Source sequence(s)
    AL132774, DQ680044, EU340241
    Consensus CDS
    CCDS47503.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    B8K2Q5
    Related
    ENSP00000394624.2, OTTHUMP00000225129, ENST00000434900.6, OTTHUMT00000375908
    Conserved Domains (2) summary
    pfam00001
    Location:180431
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:172376
    7tm_4; Olfactory receptor
  6. NM_001145280.3NP_001138752.1  mu-type opioid receptor isoform MOR-1G1

    See identical proteins and their annotated locations for NP_001138752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1G1) lacks two alternate exons and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
    Source sequence(s)
    AL132774, DQ680044, EU340242
    Consensus CDS
    CCDS55071.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    B8K2Q5
    Related
    ENSP00000430876.1, OTTHUMP00000225131, ENST00000520708.5, OTTHUMT00000375910
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  7. NM_001145281.2NP_001138753.1  mu-type opioid receptor isoform MOR-1G2

    See identical proteins and their annotated locations for NP_001138753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1G2) lacks two alternate exons and uses an alternate splice site in the 5' region, compared to variant MOR-1i. The resulting isoform (MOR-1G2) has a shorter and distinct N-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL132774, DQ680044, EU340243
    Consensus CDS
    CCDS55068.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    B8K2Q5
    Related
    ENSP00000430260.1, OTTHUMP00000225132, ENST00000518759.5, OTTHUMT00000375911
    Conserved Domains (2) summary
    pfam00001
    Location:15257
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:15202
    7tm_4; Olfactory receptor
  8. NM_001145282.2NP_001138754.1  mu-type opioid receptor isoform MOR-1B1

    See identical proteins and their annotated locations for NP_001138754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B1) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL136444, AY225404, FJ041291
    Consensus CDS
    CCDS47504.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000410497.2, OTTHUMP00000225135, ENST00000452687.6, OTTHUMT00000375915
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  9. NM_001145283.2NP_001138755.1  mu-type opioid receptor isoform MOR-1B2

    See identical proteins and their annotated locations for NP_001138755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B2) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL132774, AY309005, FJ041291
    Consensus CDS
    CCDS47505.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000413752.2, OTTHUMP00000225168, ENST00000435918.6, OTTHUMT00000375972
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  10. NM_001145284.3NP_001138756.1  mu-type opioid receptor isoform MOR-1B3

    See identical proteins and their annotated locations for NP_001138756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B3) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL132774, AY309006, FJ041291
    Consensus CDS
    CCDS47506.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000399359.2, OTTHUMP00000225167, ENST00000414028.6, OTTHUMT00000375971
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  11. NM_001145285.2NP_001138757.1  mu-type opioid receptor isoform MOR-1B4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B4) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B4) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL136444, AY309007, FJ041291
    Consensus CDS
    CCDS55069.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000430097.1, OTTHUMP00000225165, ENST00000524163.5, OTTHUMT00000375969
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  12. NM_001145286.2NP_001138758.1  mu-type opioid receptor isoform MOR-1B5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B5) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B5) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL132774, AY309008, FJ041291
    Consensus CDS
    CCDS47507.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000403549.2, OTTHUMP00000225164, ENST00000419506.6, OTTHUMT00000375968
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  13. NM_001145287.2NP_001138759.1  mu-type opioid receptor isoform MOR-1G1

    See identical proteins and their annotated locations for NP_001138759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1K1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
    Source sequence(s)
    AL132774, AL136444, EU362990
    Consensus CDS
    CCDS55071.1
    UniProtKB/Swiss-Prot
    P35372
    Related
    ENSP00000429373.1, OTTHUMP00000225170, ENST00000522236.1, OTTHUMT00000375975
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  14. NM_001285522.1NP_001272451.1  mu-type opioid receptor isoform MOR-1S

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1S) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks two alternate internal exons, compared to variant MOR-1i. The resulting isoform (MOR-1S) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
    Source sequence(s)
    AL132774, FJ041290, FJ041291
    UniProtKB/TrEMBL
    G8XRH4, G8XRH5
    Conserved Domains (2) summary
    cd14964
    Location:7396
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:7196
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. NM_001285523.2NP_001272452.1  mu-type opioid receptor isoform MOR-1A2

    See identical proteins and their annotated locations for NP_001272452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1A2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1A2) has a shorter N-terminus and a distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
    Source sequence(s)
    AY195733, FJ041291, JX914655
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5, L0E130
    Related
    ENSP00000353598.5, ENST00000360422.8
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  16. NM_001285524.1NP_001272453.1  mu-type opioid receptor isoform MOR-1i

    See identical proteins and their annotated locations for NP_001272453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1CA) represents use of an alternate promoter and 5' UTR, compared to variant MOR-1i. Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).
    Source sequence(s)
    AL132774, FJ041292
    Consensus CDS
    CCDS47503.1
    UniProtKB/Swiss-Prot
    P35372
    Conserved Domains (2) summary
    pfam00001
    Location:180431
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:172376
    7tm_4; Olfactory receptor
  17. NM_001285526.1NP_001272455.1  mu-type opioid receptor isoform MOR-1G1

    See identical proteins and their annotated locations for NP_001272455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1K2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
    Source sequence(s)
    AL132774, AL136444, EU360599
    Consensus CDS
    CCDS55071.1
    UniProtKB/Swiss-Prot
    P35372
    Related
    ENSP00000429719.1, OTTHUMP00000225169, ENST00000522555.5, OTTHUMT00000375974
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  18. NM_001285527.1NP_001272456.1  mu-type opioid receptor isoform MOR-1W

    See identical proteins and their annotated locations for NP_001272456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1W; also known as mu3-like and MOR-1A delta) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1W) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AY364890
    UniProtKB/Swiss-Prot
    P35372
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  19. NM_001285528.2NP_001272457.1  mu-type opioid receptor isoform MOR-3

    See identical proteins and their annotated locations for NP_001272457.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-3; also known as mu3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-3) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AY195733, AY364890
    UniProtKB/Swiss-Prot
    P35372
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor

RNA

  1. NR_104348.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Y3; also known as MOR-1V) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL132774, FJ041291, FJ041293, FJ041294
  2. NR_104349.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Y2) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY225404, FJ041291, FJ041294
  3. NR_104350.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Z) represents use of an alternate promoter and lacks an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL132774, FJ041291, HQ699462
  4. NR_104351.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Y) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL132774, AY309009, FJ041291
    Related
    ENST00000519083.5, OTTHUMT00000375970

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    154010496..154246867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010907.2XP_016866396.1  mu-type opioid receptor isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:135159
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:133180
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_011535862.2XP_011534164.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534164.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  3. XM_011535856.2XP_011534158.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534158.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  4. XM_011535853.2XP_011534155.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534155.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  5. XM_017010906.2XP_016866395.1  mu-type opioid receptor isoform X2

    UniProtKB/Swiss-Prot
    P35372
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  6. XM_017010903.2XP_016866392.1  mu-type opioid receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  7. XM_011535851.3XP_011534153.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534153.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  8. XM_017010905.1XP_016866394.1  mu-type opioid receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  9. XM_017010904.1XP_016866393.1  mu-type opioid receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
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