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OPRL1 opioid related nociceptin receptor 1 [ Homo sapiens (human) ]

Gene ID: 4987, updated on 17-Jun-2019

Summary

Official Symbol
OPRL1provided by HGNC
Official Full Name
opioid related nociceptin receptor 1provided by HGNC
Primary source
HGNC:HGNC:8155
See related
Ensembl:ENSG00000125510 MIM:602548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOP; OOR; NOPr; ORL1; KOR-3; NOCIR
Summary
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Broad expression in brain (RPKM 1.7), testis (RPKM 0.9) and 14 other tissues See more
Orthologs

Genomic context

See OPRL1 in Genome Data Viewer
Location:
20q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (64080082..64100643)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62711451..62731996)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SOX18 promoter region Neighboring gene transcription elongation factor A2 Neighboring gene SRY-box transcription factor 18 Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene LKAAEAR motif containing 1 Neighboring gene neuropeptides B and W receptor 2 Neighboring gene B6.7 minisatellite repeat instability region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nociceptin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nociceptin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
conditioned place preference IEA
Inferred from Electronic Annotation
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
positive regulation of urine volume IEA
Inferred from Electronic Annotation
more info
 
regulation of locomotor rhythm IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
sensory perception TAS
Traceable Author Statement
more info
PubMed 
sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nociceptin receptor
Names
kappa-type 3 opioid receptor
kappa3-related opioid receptor
nociceptin/orphanin FQ receptor
opiate receptor-like 1
orphanin FQ receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000913.6NP_000904.1  nociceptin receptor isoform 1

    See identical proteins and their annotated locations for NP_000904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' non-coding region; therefore, has a shorter 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AF285093, BC038433, CB048300, R17579
    Consensus CDS
    CCDS13556.1
    UniProtKB/Swiss-Prot
    P41146
    Related
    ENSP00000347848.4, ENST00000355631.8
    Conserved Domains (1) summary
    cd15092
    Location:52330
    7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001200019.2NP_001186948.1  nociceptin receptor isoform 1

    See identical proteins and their annotated locations for NP_001186948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 5' non-coding exons; therefore, has a different 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL590548, BC038433, CB048300, R17579
    Consensus CDS
    CCDS13556.1
    UniProtKB/Swiss-Prot
    P41146
    Related
    ENSP00000336764.3, ENST00000349451.3
    Conserved Domains (1) summary
    cd15092
    Location:52330
    7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001318853.2NP_001305782.1  nociceptin receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AF285093, BC038433, CB048300, R17579
    UniProtKB/Swiss-Prot
    P41146
    Conserved Domains (2) summary
    pfam00001
    Location:68319
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:66188
    7tm_4; Olfactory receptor
  4. NM_001318854.1NP_001305783.1  nociceptin receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate, in-frame acceptor splice site in the 5' coding region compared to variant 1. The resulting isoform (2, also known as KOR-3D) is shorter, missing a 5 aa protein segment compared to isoform 1.
    Source sequence(s)
    AF126470, AL121581, BC038433, CB048300, R17579
    UniProtKB/Swiss-Prot
    P41146
    Conserved Domains (2) summary
    pfam00001
    Location:68314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:66183
    7tm_4; Olfactory receptor
  5. NM_001318855.1NP_001305784.1  nociceptin receptor isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate acceptor splice site in the 5' coding region, which results in translation initiation from an alternate, downstream start codon compared to variant 1. The encoded isoform (3, also known as KOR-3A) is shorter, with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF115266, AL121581, BC038433, CB048300, R17579
    UniProtKB/Swiss-Prot
    P41146
    UniProtKB/TrEMBL
    Q8IXB0
    Conserved Domains (2) summary
    pfam00001
    Location:48290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:112159
    7tm_4; Olfactory receptor
  6. NM_182647.4NP_872588.1  nociceptin receptor isoform 1

    See identical proteins and their annotated locations for NP_872588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AF285093, BC038433, CB048300, R17579
    Consensus CDS
    CCDS13556.1
    UniProtKB/Swiss-Prot
    P41146
    Related
    ENSP00000336843.2, ENST00000336866.7
    Conserved Domains (1) summary
    cd15092
    Location:52330
    7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    64080082..64100643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027854.1XP_016883343.1  nociceptin receptor isoform X2

    UniProtKB/Swiss-Prot
    P41146
    Conserved Domains (1) summary
    cd15092
    Location:52330
    7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017027853.1XP_016883342.1  nociceptin receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:86337
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:84206
    7tm_4; Olfactory receptor
  3. XM_011528828.3XP_011527130.1  nociceptin receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:86337
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:84206
    7tm_4; Olfactory receptor
  4. XM_011528830.3XP_011527132.1  nociceptin receptor isoform X4

    See identical proteins and their annotated locations for XP_011527132.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:60107
    7tm_4; Olfactory receptor
  5. XM_017027855.1XP_016883344.1  nociceptin receptor isoform X3

    UniProtKB/Swiss-Prot
    P41146
    Conserved Domains (2) summary
    pfam00001
    Location:68314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:66183
    7tm_4; Olfactory receptor

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187624.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2723..5589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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