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SCAPER S-phase cyclin A associated protein in the ER [ Homo sapiens (human) ]

Gene ID: 49855, updated on 1-Aug-2020

Summary

Official Symbol
SCAPERprovided by HGNC
Official Full Name
S-phase cyclin A associated protein in the ERprovided by HGNC
Primary source
HGNC:HGNC:13081
See related
Ensembl:ENSG00000140386 MIM:611611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDDRP; ZNF291; Zfp291; MSTP063
Expression
Broad expression in testis (RPKM 4.5), brain (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See SCAPER in Genome Data Viewer
Location:
15q24.3
Exon count:
47
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (76347904..76905455, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76640526..77197796, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr15.2471 Neighboring gene Sharpr-MPRA regulatory region 228 Neighboring gene tRNA-Lys (anticodon CTT) 16-1 Neighboring gene ISL LIM homeobox 2 Neighboring gene microRNA 3713 Neighboring gene RN7SK pseudogene 217 Neighboring gene uncharacterized LOC105370904 Neighboring gene RNA, 7SL, cytoplasmic 278, pseudogene Neighboring gene reticulocalbin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31533, FLJ31953, FLJ46212, KIAA1454

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
S phase cyclin A-associated protein in the endoplasmic reticulum
Names
zinc finger protein 291

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145923.1NP_001139395.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC016343, AF119814, BX647285
    Consensus CDS
    CCDS53961.1
    UniProtKB/Swiss-Prot
    Q9BY12
    Related
    ENSP00000442190.2, ENST00000538941.6
    Conserved Domains (2) summary
    smart00451
    Location:544576
    ZnF_U1; U1-like zinc finger
    cl26511
    Location:146524
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_001353009.2NP_001339938.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform c

    Status: VALIDATED

    Source sequence(s)
    AC015798, AC016343, AC027243, AC051643, AC090179, AC090751
    Conserved Domains (3) summary
    smart00451
    Location:796828
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:89183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:395776
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_001353010.2NP_001339939.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform d

    Status: VALIDATED

    Source sequence(s)
    AC015798, AC016343, AC027243, AC051643, AC090179, AC090751
    Conserved Domains (3) summary
    smart00451
    Location:656688
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:258636
    Neuromodulin_N; Gap junction protein N-terminal region
  4. NM_001353011.2NP_001339940.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform e

    Status: VALIDATED

    Source sequence(s)
    AC015798, AC016343, AC027243, AC051643, AC090179, AC090751
    Conserved Domains (3) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:261642
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001353012.2NP_001339941.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform d

    Status: VALIDATED

    Source sequence(s)
    AC015798, AC016343, AC027243, AC051643, AC090179, AC090751
    Conserved Domains (3) summary
    smart00451
    Location:656688
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:258636
    Neuromodulin_N; Gap junction protein N-terminal region
  6. NM_020843.4NP_065894.2  S phase cyclin A-associated protein in the endoplasmic reticulum isoform a

    See identical proteins and their annotated locations for NP_065894.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC015798, AC016343, AC027243, AC051643, AC090179, AC090751
    Consensus CDS
    CCDS53962.1
    UniProtKB/Swiss-Prot
    Q9BY12
    Related
    ENSP00000454973.1, ENST00000563290.6
    Conserved Domains (5) summary
    smart00451
    Location:790822
    ZnF_U1; U1-like zinc finger
    pfam00836
    Location:529626
    Stathmin; Stathmin family
    pfam16501
    Location:89183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cd16269
    Location:760770
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:670774
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_148227.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015798, AC016343, AC027243, AC051643, AC090179, AC090751

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    76347904..76905455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022272.1XP_016877761.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X3

  2. XM_005254417.2XP_005254474.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    See identical proteins and their annotated locations for XP_005254474.1

    Conserved Domains (3) summary
    smart00451
    Location:796828
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:89183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:395776
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_017022273.1XP_016877762.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X5

    Conserved Domains (3) summary
    smart00451
    Location:656688
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:258636
    Neuromodulin_N; Gap junction protein N-terminal region
  4. XM_011521653.3XP_011519955.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X4

    See identical proteins and their annotated locations for XP_011519955.1

    Conserved Domains (3) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:261642
    Neuromodulin_N; Gap junction protein N-terminal region
  5. XM_017022270.1XP_016877759.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

    UniProtKB/Swiss-Prot
    Q9BY12
    Conserved Domains (5) summary
    smart00451
    Location:790822
    ZnF_U1; U1-like zinc finger
    pfam00836
    Location:529626
    Stathmin; Stathmin family
    pfam16501
    Location:89183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cd16269
    Location:760770
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:670774
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. XM_017022278.2XP_016877767.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X10

  7. XM_017022269.1XP_016877758.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

    UniProtKB/Swiss-Prot
    Q9BY12
    Related
    ENSP00000326924.7, ENST00000324767.11
    Conserved Domains (5) summary
    smart00451
    Location:790822
    ZnF_U1; U1-like zinc finger
    pfam00836
    Location:529626
    Stathmin; Stathmin family
    pfam16501
    Location:89183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cd16269
    Location:760770
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:670774
    GBP_C; Guanylate-binding protein, C-terminal domain
  8. XM_017022277.2XP_016877766.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X10

  9. XM_024449939.1XP_024305707.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X8

    Conserved Domains (2) summary
    smart00451
    Location:544576
    ZnF_U1; U1-like zinc finger
    cl26511
    Location:146524
    Neuromodulin_N; Gap junction protein N-terminal region
  10. XM_024449938.1XP_024305706.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X7

    Conserved Domains (2) summary
    smart00451
    Location:550582
    ZnF_U1; U1-like zinc finger
    cl26511
    Location:149530
    Neuromodulin_N; Gap junction protein N-terminal region
  11. XM_017022275.2XP_016877764.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X9

  12. XM_017022268.1XP_016877757.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    Conserved Domains (3) summary
    smart00451
    Location:796828
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:89183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl26511
    Location:395776
    Neuromodulin_N; Gap junction protein N-terminal region
  13. XM_017022276.1XP_016877765.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X9

  14. XM_011521656.3XP_011519958.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X17

    Conserved Domains (5) summary
    smart00451
    Location:176208
    ZnF_U1; U1-like zinc finger
    pfam11600
    Location:28182
    CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
    cd16269
    Location:146156
    GBP_C; coiled coil [structural motif]
    cl00220
    Location:543584
    cysteine_hydrolases; Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It ...
    cl20817
    Location:56160
    GBP_C; Guanylate-binding protein, C-terminal domain
  15. XM_024449937.1XP_024305705.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X6

    Conserved Domains (4) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl25732
    Location:223580
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:413642
    Neuromodulin_N; Gap junction protein N-terminal region
  16. XM_024449942.1XP_024305710.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X13

    Conserved Domains (4) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl25732
    Location:223580
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:413642
    Neuromodulin_N; Gap junction protein N-terminal region
  17. XM_024449941.1XP_024305709.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X12

    Conserved Domains (4) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl25732
    Location:223580
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:413642
    Neuromodulin_N; Gap junction protein N-terminal region
  18. XM_024449943.1XP_024305711.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X14

    Conserved Domains (4) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl25732
    Location:223580
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:413642
    Neuromodulin_N; Gap junction protein N-terminal region
  19. XM_024449940.1XP_024305708.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X11

    Conserved Domains (4) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl25732
    Location:223580
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:413642
    Neuromodulin_N; Gap junction protein N-terminal region
  20. XM_024449944.1XP_024305712.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X15

    Conserved Domains (4) summary
    smart00451
    Location:662694
    ZnF_U1; U1-like zinc finger
    pfam16501
    Location:149
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl25732
    Location:223580
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:413642
    Neuromodulin_N; Gap junction protein N-terminal region
  21. XM_017022283.1XP_016877772.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X16

    Related
    ENSP00000456508.1, ENST00000564590.5

RNA

  1. XR_002957646.1 RNA Sequence

  2. XR_002957647.1 RNA Sequence

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