Format

Send to:

Choose Destination

ZBTB21 zinc finger and BTB domain containing 21 [ Homo sapiens (human) ]

Gene ID: 49854, updated on 12-Oct-2019

Summary

Official Symbol
ZBTB21provided by HGNC
Official Full Name
zinc finger and BTB domain containing 21provided by HGNC
Primary source
HGNC:HGNC:13083
See related
Ensembl:ENSG00000173276 MIM:616485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF295
Expression
Ubiquitous expression in adrenal (RPKM 15.8), gall bladder (RPKM 5.4) and 23 other tissues See more
Orthologs

Genomic context

See ZBTB21 in Genome Data Viewer
Location:
21q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (41986831..42010418, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43406940..43430496, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene PR/SET domain 15 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene small nucleolar RNA, H/ACA box 91 Neighboring gene ZNF295 antisense RNA 1 Neighboring gene uncharacterized LOC107985502 Neighboring gene uromodulin like 1 Neighboring gene UMODL1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781N1974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 21
Names
zinc finger protein 295

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098402.2NP_001091872.1  zinc finger and BTB domain-containing protein 21 isoform L

    See identical proteins and their annotated locations for NP_001091872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate exon in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, BP230048
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Related
    ENSP00000308759.5, ENST00000310826.10
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  2. NM_001098403.2NP_001091873.1  zinc finger and BTB domain-containing protein 21 isoform S

    See identical proteins and their annotated locations for NP_001091873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 5. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
    Source sequence(s)
    AB041015, BP230048
    Consensus CDS
    CCDS42934.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Related
    ENSP00000381517.3, ENST00000398505.7
    Conserved Domains (3) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  3. NM_001320729.2NP_001307658.1  zinc finger and BTB domain-containing protein 21 isoform S

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 1. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
    Source sequence(s)
    AB041015, BC063290, BP230048
    Consensus CDS
    CCDS42934.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (3) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  4. NM_001320731.2NP_001307660.1  zinc finger and BTB domain-containing protein 21 isoform L

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, AB041015, AJ003669, BC063290, CR933655
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    UniProtKB/TrEMBL
    Q5H9S0
    Related
    ENSP00000381512.1, ENST00000398499.5
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  5. NM_020727.5NP_065778.3  zinc finger and BTB domain-containing protein 21 isoform L

    See identical proteins and their annotated locations for NP_065778.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, BC063290, BP230048
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Related
    ENSP00000381523.3, ENST00000398511.3
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    41986831..42010418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529588.2XP_011527890.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011527890.1

    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  2. XM_017028360.1XP_016883849.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  3. XM_017028361.1XP_016883850.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  4. XM_005261121.3XP_005261178.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_005261178.1

    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  5. XM_011529590.2XP_011527892.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011527892.1

    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (5) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
Support Center