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ZBTB21 zinc finger and BTB domain containing 21 [ Homo sapiens (human) ]

Gene ID: 49854, updated on 4-Dec-2022

Summary

Official Symbol
ZBTB21provided by HGNC
Official Full Name
zinc finger and BTB domain containing 21provided by HGNC
Primary source
HGNC:HGNC:13083
See related
Ensembl:ENSG00000173276 MIM:616485; AllianceGenome:HGNC:13083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF295
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 15.8), gall bladder (RPKM 5.4) and 23 other tissues See more
Orthologs
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Genomic context

See ZBTB21 in Genome Data Viewer
Location:
21q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (41986831..42010360, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (40377057..40400598, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43406940..43430469, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene PR/SET domain 15 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene small nucleolar RNA, H/ACA box 91 Neighboring gene ZNF295 antisense RNA 1 Neighboring gene uncharacterized LOC107985502 Neighboring gene uromodulin like 1 Neighboring gene UMODL1 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781N1974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables POZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 21
Names
zinc finger protein 295

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098402.2NP_001091872.1  zinc finger and BTB domain-containing protein 21 isoform L

    See identical proteins and their annotated locations for NP_001091872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate exon in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, BP230048
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q6P4R0, Q9ULJ3
    Related
    ENSP00000308759.5, ENST00000310826.10
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  2. NM_001098403.2NP_001091873.1  zinc finger and BTB domain-containing protein 21 isoform S

    See identical proteins and their annotated locations for NP_001091873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 5. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
    Source sequence(s)
    AB041015, BP230048
    Consensus CDS
    CCDS42934.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Related
    ENSP00000381517.3, ENST00000398505.7
    Conserved Domains (3) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  3. NM_001320729.2NP_001307658.1  zinc finger and BTB domain-containing protein 21 isoform S

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 1. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
    Source sequence(s)
    AB041015, BC063290, BP230048
    Consensus CDS
    CCDS42934.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (3) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  4. NM_001320731.2NP_001307660.1  zinc finger and BTB domain-containing protein 21 isoform L

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, AB041015, AJ003669, BC063290, CR933655
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q6P4R0, Q9ULJ3
    UniProtKB/TrEMBL
    Q5H9S0
    Related
    ENSP00000381512.1, ENST00000398499.5
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  5. NM_020727.5NP_065778.3  zinc finger and BTB domain-containing protein 21 isoform L

    See identical proteins and their annotated locations for NP_065778.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, BC063290, BP230048
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q6P4R0, Q9ULJ3
    Related
    ENSP00000381523.3, ENST00000398511.3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    41986831..42010360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440793.1XP_047296749.1  zinc finger and BTB domain-containing protein 21 isoform X2

  2. XM_011529588.3XP_011527890.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011527890.1

    UniProtKB/Swiss-Prot
    Q6P4R0, Q9ULJ3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  3. XM_047440788.1XP_047296744.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0
  4. XM_047440792.1XP_047296748.1  zinc finger and BTB domain-containing protein 21 isoform X2

  5. XM_017028360.2XP_016883849.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0, Q9ULJ3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  6. XM_047440794.1XP_047296750.1  zinc finger and BTB domain-containing protein 21 isoform X2

  7. XM_047440786.1XP_047296742.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0
  8. XM_047440795.1XP_047296751.1  zinc finger and BTB domain-containing protein 21 isoform X2

  9. XM_047440790.1XP_047296746.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0
  10. XM_047440787.1XP_047296743.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0
  11. XM_047440796.1XP_047296752.1  zinc finger and BTB domain-containing protein 21 isoform X2

  12. XM_047440791.1XP_047296747.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0
  13. XM_005261121.4XP_005261178.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_005261178.1

    UniProtKB/Swiss-Prot
    Q6P4R0, Q9ULJ3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  14. XM_047440797.1XP_047296753.1  zinc finger and BTB domain-containing protein 21 isoform X2

  15. XM_047440789.1XP_047296745.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6P4R0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    40377057..40400598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)