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Tnfrsf11a TNF receptor superfamily member 11A [ Rattus norvegicus (Norway rat) ]

Gene ID: 498206, updated on 19-Apr-2019

Summary

Official Symbol
Tnfrsf11aprovided by RGD
Official Full Name
TNF receptor superfamily member 11Aprovided by RGD
Primary source
RGD:1563614
See related
Ensembl:ENSRNOG00000015615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RANK; RGD1563614
Expression
Biased expression in Lung (RPKM 26.6), Brain (RPKM 24.0) and 9 other tissues See more
Orthologs

Genomic context

See Tnfrsf11a in Genome Data Viewer
Location:
13p11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25778306..25835802)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (30966261..30997692)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class N Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing Neighboring gene uncharacterized LOC102549134 Neighboring gene uncharacterized LOC108352516

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine binding IEA
Inferred from Electronic Annotation
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
tumor necrosis factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
TNFSF11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response ISO
Inferred from Sequence Orthology
more info
PubMed 
circadian temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
circadian temperature homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
lymph node development IEA
Inferred from Electronic Annotation
more info
 
lymph node development ISO
Inferred from Sequence Orthology
more info
PubMed 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
PubMed 
multicellular organism development ISO
Inferred from Sequence Orthology
more info
PubMed 
multinuclear osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
multinuclear osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
ossification ISO
Inferred from Sequence Orthology
more info
PubMed 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fever generation by positive regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fever generation by positive regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
PubMed 
response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
PubMed 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
PubMed 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 11A
Names
tumor necrosis factor receptor superfamily, member 11a, NFKB activator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271235.1NP_001258164.1  tumor necrosis factor receptor superfamily member 11A precursor

    Status: VALIDATED

    Source sequence(s)
    AABR07020431, AABR07020433, AABR07020434
    UniProtKB/TrEMBL
    F1M8Z6
    Related
    ENSRNOP00000021129.4, ENSRNOT00000021129.4
    Conserved Domains (1) summary
    cd13411
    Location:34196
    TNFRSF11A; Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    25778306..25835802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769487.2XP_008767709.1  tumor necrosis factor receptor superfamily member 11A isoform X1

    Conserved Domains (1) summary
    cl22855
    Location:104154
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    21798588..21856355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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