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Ace3 angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498012, updated on 12-Aug-2018

Summary

Official Symbol
Ace3provided by RGD
Official Full Name
angiotensin I converting enzyme (peptidyl-dipeptidase A) 3provided by RGD
Primary source
RGD:1561299
See related
Ensembl:ENSRNOG00000007467 Vega:OTTRNOG00000002215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561299
Expression
Restricted expression toward (RPKM 47.9) See more

Genomic context

See Ace3 in Genome Data Viewer
Location:
10q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94191699..94206276)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (93943839..93957570)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene angiotensin-converting enzyme-like Neighboring gene cytochrome b-561 Neighboring gene uncharacterized LOC102556428 Neighboring gene uncharacterized LOC108352145 Neighboring gene angiotensin I converting enzyme Neighboring gene potassium voltage-gated channel subfamily H member 6 Neighboring gene DDB1 and CUL4 associated factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Renin - Angiotensin System, organism-specific biosystem (from WikiPathways)
    Renin - Angiotensin System, organism-specific biosystemThis pathway is based on the [http://www.genome.jp/dbget-bin/show_pathway?map04614+C15850 KEGG pathway] of renin-angiotensin and the [http://www.ambion.com/tools/pathway/pathway.php?pathway=Renin-Ang...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
NP_001245166.1
XP_017452961.1
XP_017452962.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258237.1NP_001245166.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 precursor

    Status: VALIDATED

    Source sequence(s)
    BC085122
    UniProtKB/TrEMBL
    M0RB66
    Conserved Domains (1) summary
    pfam01401
    Location:34610
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    94191699..94206276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597472.1XP_017452961.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X1

    UniProtKB/TrEMBL
    M0RB66
    Related
    ENSRNOP00000075972.1, OTTRNOP00000002152, ENSRNOT00000093039.1, OTTRNOT00000003757
    Conserved Domains (1) summary
    pfam01401
    Location:34610
    Peptidase_M2; Angiotensin-converting enzyme
  2. XM_017597473.1XP_017452962.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X1

    UniProtKB/TrEMBL
    M0RB66
    Related
    ENSRNOP00000066793.1, ENSRNOT00000074007.2
    Conserved Domains (1) summary
    pfam01401
    Location:34610
    Peptidase_M2; Angiotensin-converting enzyme

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    89613301..89626995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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