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Zfp3 zinc finger protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497944, updated on 10-Jul-2024

Summary

Official Symbol
Zfp3provided by RGD
Official Full Name
zinc finger protein 3provided by RGD
Primary source
RGD:1565881
See related
EnsemblRapid:ENSRNOG00000005009 AllianceGenome:RGD:1565881
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565881
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human ZFP3 (ZFP3 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 69.4), Heart (RPKM 47.1) and 9 other tissues See more
Orthologs
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Genomic context

See Zfp3 in Genome Data Viewer
Location:
10q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55977027..55985284)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55478424..55486686)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57386228..57394471)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene kinesin family member 1C Neighboring gene uncharacterized LOC120095132 Neighboring gene SLP adaptor and CSK interacting membrane protein Neighboring gene uncharacterized LOC120095133

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109034.1NP_001102504.1  zinc finger protein 3 homolog

    See identical proteins and their annotated locations for NP_001102504.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HG99, D3ZIG3
    Related
    ENSRNOP00000006641.4, ENSRNOT00000006641.7
    Conserved Domains (4) summary
    COG5048
    Location:122496
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:172192
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:142164
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:380405
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55977027..55985284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)