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Dut deoxyuridine triphosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 497778, updated on 3-Jan-2019

Summary

Official Symbol
Dutprovided by RGD
Official Full Name
deoxyuridine triphosphataseprovided by RGD
Primary source
RGD:620849
See related
Ensembl:ENSRNOG00000007221
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dutp; PIP4
Summary
precursor of thymidine nucleotides; may inhibit peroxisome proliferator-activated receptor (PPAR) activity [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 344.2), Thymus (RPKM 330.1) and 9 other tissues See more
Orthologs

Genomic context

See Dut in Genome Data Viewer
Location:
3q36
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117514399..117525450)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (124038120..124049168)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 1 Neighboring gene uncharacterized LOC102555270 Neighboring gene ribosomal protein L32, pseudogene 1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene fibrillin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
dUTP diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dUTP diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
dUTP diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyrimidine deoxyribonucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
receptor inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dUMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dUMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
dUMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dUTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dUTP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
deoxyuridine 5'-triphosphate nucleotidohydrolase
Names
PPAR-interacting protein 4
dUTP pyrophosphatase
dUTPase
NP_001035361.1
NP_446044.1
XP_008760410.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040271.1NP_001035361.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_001035361.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI705003, AW530495, CB325379, U64030
    UniProtKB/Swiss-Prot
    P70583
    Conserved Domains (1) summary
    cl00493
    Location:2159
    trimeric_dUTPase; Trimeric dUTP diphosphatases
  2. NM_053592.2NP_446044.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_446044.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI705003, CB325379, U64030
    UniProtKB/Swiss-Prot
    P70583
    Related
    ENSRNOP00000009549.1, ENSRNOT00000009549.2
    Conserved Domains (1) summary
    cl00493
    Location:51203
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    117514399..117525450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762188.1XP_008760410.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X1

    Conserved Domains (1) summary
    cl00493
    Location:66163
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RNA

  1. XR_591634.2 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    111355479..111366436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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