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Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497757, updated on 3-Jun-2018
Official Symbol
Gucy1a1provided by RGD
Official Full Name
guanylate cyclase 1 soluble subunit alpha 1provided by RGD
Primary source
RGD:68436
See related
Ensembl:ENSRNOG00000012302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SGC; Gucy1a3
Summary
soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 322.0), Thymus (RPKM 151.8) and 9 other tissues See more
Orthologs
See Gucy1a1 in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (181045694..181103321, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (200453480..200515219, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit family member 5 Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene uncharacterized LOC108350044 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial pseudogene

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Long-term depression, organism-specific biosystem (from KEGG)
    Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Long-term depression, conserved biosystem (from KEGG)
    Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
    Nitric oxide stimulates guanylate cyclase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cGMP signaling, organism-specific biosystem (from KEGG)
    cGMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • cGMP signaling, conserved biosystem (from KEGG)
    cGMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytidylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
guanylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
relaxation of vascular smooth muscle IEA
Inferred from Electronic Annotation
more info
 
relaxation of vascular smooth muscle ISO
Inferred from Sequence Orthology
more info
 
response to defense-related host nitric oxide production IEA
Inferred from Electronic Annotation
more info
 
response to defense-related host nitric oxide production ISO
Inferred from Sequence Orthology
more info
 
response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
guanylate cyclase complex, soluble IDA
Inferred from Direct Assay
more info
PubMed 
guanylate cyclase complex, soluble IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase complex, soluble ISO
Inferred from Sequence Orthology
more info
 
guanylate cyclase complex, soluble TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3
Names
GCS-alpha-1
GCS-alpha-3
Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase)
guanylate cyclase 1 soluble subunit alpha 3
guanylate cyclase 1, soluble, alpha 3
soluble guanylate cyclase large subunit
NP_058786.2
XP_006232580.1
XP_008759329.1
XP_017446500.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017090.2NP_058786.2  guanylate cyclase soluble subunit alpha-1

    See identical proteins and their annotated locations for NP_058786.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085746
    UniProtKB/TrEMBL
    Q5U330
    Related
    ENSRNOP00000017190.2, ENSRNOT00000017190.4
    Conserved Domains (4) summary
    smart00044
    Location:444633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276465
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    181045694..181103321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232518.3XP_006232580.1  guanylate cyclase soluble subunit alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_006232580.1

    UniProtKB/TrEMBL
    Q5U330
    Conserved Domains (4) summary
    smart00044
    Location:444633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276465
    HNOBA; Heme NO binding associated
  2. XM_017591011.1XP_017446500.1  guanylate cyclase soluble subunit alpha-3 isoform X1

    UniProtKB/TrEMBL
    Q5U330
    Conserved Domains (4) summary
    smart00044
    Location:444633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276465
    HNOBA; Heme NO binding associated
  3. XM_008761107.2XP_008759329.1  guanylate cyclase soluble subunit alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_008759329.1

    UniProtKB/TrEMBL
    Q5U330
    Conserved Domains (4) summary
    smart00044
    Location:444633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276465
    HNOBA; Heme NO binding associated

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    161450514..161511622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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