U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Si sucrase-isomaltase [ Rattus norvegicus (Norway rat) ]

Gene ID: 497756, updated on 3-Jun-2026
Official Symbol
Siprovided by RGD
Official Full Name
sucrase-isomaltaseprovided by RGD
Primary source
RGD:3675
See related
Ensembl:ENSRNOG00000031067 AllianceGenome:RGD:3675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SUCIMAL
Summary
Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including carbohydrate utilization; intestinal epithelial cell maturation; and response to cortisone. Located in several cellular components, including Golgi cisterna; cell projection membrane; and multivesicular body. Biomarker of colitis and exocrine pancreatic insufficiency. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 4.9) and Brain (RPKM 1.9) See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
Location:
2q32
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (159804568..159884902, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (157505893..157586228, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (170220794..170301348, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, pseudogene 6 Neighboring gene ribosomal protein L26-like 1, pseudogene 2 Neighboring gene SLIT and NTRK-like family, member 3 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 26

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Immunoelectron microscopic localization of sucrase-isomaltase in rat small intestine. Noda S, et al. J Nutr Sci Vitaminol (Tokyo), 1993 Apr. PMID 8410378
  2. Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression. Aoki K, et al. Br J Nutr, 2023 Jul 14. PMID 36329653
  3. Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression. Kitchen PA, et al. Am J Physiol Gastrointest Liver Physiol, 2000 Mar. PMID 10712262
  4. Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance. Adachi T, et al. Biochim Biophys Acta, 1999 Jan 4. PMID 9878708
  5. Expression of intestinal brush-border membrane hydrolases and ferritin after segmental ischemia-reperfusion in rats. Yeh KY, et al. Am J Physiol, 1998 Sep. PMID 9724271

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression.
    Title: Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression.
  2. harmaline has an effect on rat intestinal brush border sucrase activity
    Title: Effect of harmaline on rat intestinal brush border sucrase activity.
  3. An abrupt jejunal induction of histone acetylation changes on the sucrase-isomaltase gene during this period may be concerned with the expression of the gene.
    Title: Induction of histone acetylation on the sucrase-isomaltase gene in the postnatal rat jejunum.
  4. The antidiabetic effect of tungstate is partly due to normalization of the activity of sucrase and SGLT1 in the brush-border membrane of enterocytes.
    Title: Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats.
  5. These results suggest that induction of the SI gene during the transition from the crypt to the villi is associated with changes in histone H3 modifications from methylation at lysine 9 to di-acetylation at lysine 9/14.
    Title: Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats.
  6. Spermidine induction of sucrase-isomaltase in small intestine may be mediated by altered ornithine decarboxylase expression.
    Title: Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,4-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-fructofuranosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables oligo-1,6-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oligo-1,6-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables oligo-1,6-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sucrose alpha-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sucrose alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables sucrose alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate utilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intestinal epithelial cell maturation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cortisone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to food IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to fructose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to muscle activity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to sucrose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to triglyceride IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sucrose catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
sucrase-isomaltase, intestinal
Names
sucrase-isomaltase (alpha-glucosidase)
NP_001376155.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389226.1 → NP_001376155.1  sucrase-isomaltase, intestinal

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0ABK0LCM4
    Related
    ENSRNOP00000045106.5, ENSRNOT00000046681.6
    Conserved Domains (6) summary
    smart00018
    Location:944 → 990
    PD; P or trefoil or TFF domain
    cd06602
    Location:353 → 717
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:237 → 353
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:80 → 118
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:1204 → 1700
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:135 → 244
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    159804568..159884902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013061.1: Suppressed sequence

    Description
    NM_013061.1: This RefSeq was removed because currently there is insufficient support for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23739.5 GenPept UniProtKB/Swiss-Prot:P23739

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools