U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C18orf32 chromosome 18 open reading frame 32 [ Homo sapiens (human) ]

Gene ID: 497661, updated on 5-Jul-2025
Official Symbol
C18orf32provided by HGNC
Official Full Name
chromosome 18 open reading frame 32provided by HGNC
Primary source
HGNC:HGNC:31690
See related
Ensembl:ENSG00000177576 MIM:619979; AllianceGenome:HGNC:31690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPIBD25
Summary
Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in brain (RPKM 45.1), kidney (RPKM 32.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See C18orf32 in Genome Data Viewer
Location:
18q21.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (49477243..49487234, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49674978..49684975, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47003613..47013604, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene dymeclin Neighboring gene uncharacterized LOC124904298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46713027-46713528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46713529-46714028 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:46729371-46730248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13308 Neighboring gene NANOG hESC enhancer GRCh37_chr18:46845924-46846499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9448 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46991502-46992276 Neighboring gene RPL17-C18orf32 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13309 Neighboring gene proline rich 13 pseudogene 4 Neighboring gene small nucleolar RNA, C/D box 58C Neighboring gene microRNA 1539 Neighboring gene ribosomal protein L17

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ23458

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
UPF0729 protein C18orf32
Names
putative NF-kappa-B-activating protein 200
putative NFkB activating protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035005.4NP_001030177.1  UPF0729 protein C18orf32

    See identical proteins and their annotated locations for NP_001030177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100778, BC022357, BC093004, BF210402, BF512018, BP395434, CB852935
    Consensus CDS
    CCDS32831.1
    UniProtKB/Swiss-Prot
    Q8TCD1
    Related
    ENSP00000323199.3, ENST00000318240.8
    Conserved Domains (1) summary
    pfam14975
    Location:247
    DUF4512; Domain of unknown function (DUF4512)
  2. NM_001199346.2NP_001186275.1  UPF0729 protein C18orf32

    See identical proteins and their annotated locations for NP_001186275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100778, BC022357, BF512018, BP395434, CB852935
    Consensus CDS
    CCDS32831.1
    UniProtKB/Swiss-Prot
    Q8TCD1
    Related
    ENSP00000480941.1, ENST00000613385.4
    Conserved Domains (1) summary
    pfam14975
    Location:247
    DUF4512; Domain of unknown function (DUF4512)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    49477243..49487234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    49674978..49684975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)