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C18orf32 chromosome 18 open reading frame 32 [ Homo sapiens (human) ]

Gene ID: 497661, updated on 23-Nov-2021

Summary

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Official Symbol
C18orf32provided by HGNC
Official Full Name
chromosome 18 open reading frame 32provided by HGNC
Primary source
HGNC:HGNC:31690
See related
Ensembl:ENSG00000177576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 45.1), kidney (RPKM 32.7) and 25 other tissues See more
Orthologs
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Genomic context

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See C18orf32 in Genome Data Viewer
Location:
18q21.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (49477243..49487234, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47003613..47013604, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene microRNA 4744 Neighboring gene dymeclin Neighboring gene RPL17-C18orf32 readthrough Neighboring gene proline rich 13 pseudogene 4 Neighboring gene small nucleolar RNA, C/D box 58C Neighboring gene microRNA 1539 Neighboring gene ribosomal protein L17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes. Bersuker K, et al. Dev Cell, 2018 Jan 8. PMID 29275994, Free PMC Article
  2. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. Huang X, et al. Mol Endocrinol, 2013 Sep. PMID 23864651, Free PMC Article
  3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  4. Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. Hannigan MM, et al. Mol Cell Proteomics, 2020 Nov. PMID 32788342, Free PMC Article
  5. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article

See all (10) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23458

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UPF0729 protein C18orf32
Names
putative NF-kappa-B-activating protein 200
putative NFkB activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035005.4 → NP_001030177.1  UPF0729 protein C18orf32

    See identical proteins and their annotated locations for NP_001030177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100778, BC022357, BC093004, BF210402, BF512018, BP395434, CB852935
    Consensus CDS
    CCDS32831.1
    UniProtKB/Swiss-Prot
    Q8TCD1
    Related
    ENSP00000323199.3, ENST00000318240.8
    Conserved Domains (1) summary
    pfam14975
    Location:2 → 47
    DUF4512; Domain of unknown function (DUF4512)

  2. NM_001199346.2 → NP_001186275.1  UPF0729 protein C18orf32

    See identical proteins and their annotated locations for NP_001186275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100778, BC022357, BF512018, BP395434, CB852935
    Consensus CDS
    CCDS32831.1
    UniProtKB/Swiss-Prot
    Q8TCD1
    Related
    ENSP00000480941.1, ENST00000613385.4
    Conserved Domains (1) summary
    pfam14975
    Location:2 → 47
    DUF4512; Domain of unknown function (DUF4512)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    49477243..49487234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCD1.1 GenPept UniProtKB/Swiss-Prot:Q8TCD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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