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HFE homeostatic iron regulator [ Bos taurus (domestic cattle) ]

Gene ID: 497622, updated on 30-Jan-2025
Official Symbol
HFEprovided by VGNC
Official Full Name
homeostatic iron regulatorprovided by VGNC
Primary source
VGNC:VGNC:29831
See related
EnsemblRapid:ENSBTAG00070005814
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See HFE in Genome Data Viewer
Location:
chromosome: 23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (31855157..31864283, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 4 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H4 clustered histone 3 Neighboring gene uncharacterized LOC112443801 Neighboring gene H1.2 linker histone, cluster member

Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transferrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of iron ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to iron ion starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
hereditary hemochromatosis protein
Names
hemochromatosis

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012399.1 → NP_001012399.1  hereditary hemochromatosis protein precursor

    See identical proteins and their annotated locations for NP_001012399.1

    Status: PROVISIONAL

    Source sequence(s)
    AY898807
    UniProtKB/TrEMBL
    A0AAA9TE31, E1BKY1, Q5EEZ1
    Related
    ENSBTAP00070007660.1, ENSBTAT00070013322.1
    Conserved Domains (2) summary
    cd07698
    Location:214 → 306
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:27 → 207
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31855157..31864283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024983413.2 → XP_024839181.1  hereditary hemochromatosis protein isoform X1

    UniProtKB/TrEMBL
    A0AAA9RY49, A0AAF6DLK8
    Related
    ENSBTAP00070007651.1, ENSBTAT00070013313.1
    Conserved Domains (2) summary
    cd07698
    Location:200 → 292
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:12 → 193
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. XR_003031981.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Research Materials
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