U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pnkd PNKD metallo-beta-lactamase domain containing [ Danio rerio (zebrafish) ]

Gene ID: 497562, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
pnkdprovided by ZNC
Official Full Name
PNKD metallo-beta-lactamase domain containingprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-278
See related
Ensembl:ENSDARG00000071032 AllianceGenome:ZFIN:ZDB-GENE-050208-278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7147352
Summary
Predicted to enable hydrolase activity. Predicted to act upstream of or within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to human PNKD (PNKD metallo-beta-lactamase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pnkd in Genome Data Viewer
Location:
chromosome: 6
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (13024448..13037815)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12789590..12802957)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:ch73-71c20.5 Neighboring gene transmembrane BAX inhibitor motif containing 1a Neighboring gene ciliogenesis associated TTC17 interacting protein Neighboring gene caspase 8, apoptosis-related cysteine peptidase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable hydrolase PNKD
Names
PNKD, MBL domain containing
myofibrillogenesis regulator 1
paroxysmal nonkinesigenic dyskinesia
NP_001243139.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256210.1 → NP_001243139.1  probable hydrolase PNKD

    Status: VALIDATED

    Source sequence(s)
    CU639421
    UniProtKB/TrEMBL
    A0A8M1P2H3, F6NM08
    Related
    ENSDARP00000095538.2, ENSDART00000104768.3
    Conserved Domains (3) summary
    TIGR03413
    Location:96 → 358
    GSH_gloB; hydroxyacylglutathione hydrolase
    pfam16123
    Location:268 → 356
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:97 → 267
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    13024448..13037815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous