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pkd1l2a polycystic kidney disease 1 like 2a [ Danio rerio (zebrafish) ]

Gene ID: 497373, updated on 4-Jan-2025

Summary

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Official Symbol
pkd1l2aprovided by ZNC
Official Full Name
polycystic kidney disease 1 like 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-89
See related
Ensembl:ENSDARG00000105344 AllianceGenome:ZFIN:ZDB-GENE-050208-89
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pkd1l3; im:7138475
Summary
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. Is expressed in pharyngeal arch cartilage; pharynx; retinal neural layer; and spinal cord. Orthologous to human PKD1L2 (polycystin 1 like 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pkd1l2a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (65176610..65236659, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (64952582..64978018, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene small nucleolar RNA SNORA23 Neighboring gene small nucleolar RNA SNORA23 Neighboring gene beta-carotene oxygenase 1, like Neighboring gene beta-carotene oxygenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Prendergast AE, et al. Curr Biol, 2023 Mar 13. PMID 36791723
  2. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polycystic kidney disease 1 like 2a; polycystin-1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    65176610..65236659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357234.3 → XP_017212723.2  polycystin-1-like protein 2

    UniProtKB/TrEMBL
    A0A2R8Q5E7, A0A3G1GTC1
    Related
    ENSDARP00000148326.1, ENSDART00000185070.1
    Conserved Domains (6) summary
    cd00037
    Location:40 → 159
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00089
    Location:275 → 346
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    cd01752
    Location:1406 → 1525
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam02140
    Location:174 → 258
    Gal_Lectin; Galactose binding lectin domain
    cl02559
    Location:1298 → 1343
    GPS; GPCR proteolysis site, GPS, motif
    cl27887
    Location:2025 → 2437
    PKD_channel; Polycystin cation channel
Nucleotide Protein Strain
Heading Accession and Version

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