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hif1al2 hypoxia inducible factor 1 subunit alpha, like 2 [ Danio rerio (zebrafish) ]

Gene ID: 497283, updated on 2-Oct-2018

Summary

Official Symbol
hif1al2provided by ZNC
Official Full Name
hypoxia inducible factor 1 subunit alpha, like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050211-2
See related
Ensembl:ENSDARG00000044550 Vega:OTTDARG00000021049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
hif1al; zgc:112119

Genomic context

See hif1al2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (27327424..27339396, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (27290729..27302656, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkey-175m17.6 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Neighboring gene dipeptidyl-peptidase 3 Neighboring gene Ras and Rab interactor 1a

Genomic regions, transcripts, and products

General gene information

Clone Names

  • MGC112119

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hypoxia-inducible factor 1, alpha subunit, like 2
Names
HIF3B
Hif2a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012371.2NP_001012371.2  hypoxia-inducible factor 1, alpha subunit, like 2

    See identical proteins and their annotated locations for NP_001012371.2

    Status: VALIDATED

    Source sequence(s)
    BX530031, CK030317, DT057411
    UniProtKB/TrEMBL
    F1QQQ1
    Related
    ENSDARP00000108595.2, OTTDARP00000021817, ENSDART00000130632.4, OTTDART00000026595
    Conserved Domains (6) summary
    cd00083
    Location:3686
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:243340
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:111184
    PAS; PAS fold
    pfam08447
    Location:254341
    PAS_3; PAS fold
    pfam08778
    Location:620656
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:429461
    HIF-1; Hypoxia-inducible factor-1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    27327424..27339396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161350.4XP_005161407.1  hypoxia-inducible factor 1, alpha subunit, like 2 isoform X1

    See identical proteins and their annotated locations for XP_005161407.1

    UniProtKB/TrEMBL
    F1QQQ1
    Conserved Domains (6) summary
    cd00083
    Location:3686
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:243340
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:111184
    PAS; PAS fold
    pfam08447
    Location:254341
    PAS_3; PAS fold
    pfam08778
    Location:620656
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:429461
    HIF-1; Hypoxia-inducible factor-1
  2. XM_021468817.1XP_021324492.1  hypoxia-inducible factor 1, alpha subunit, like 2 isoform X2

    Conserved Domains (3) summary
    cd00130
    Location:176273
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08778
    Location:553589
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:363394
    HIF-1; Hypoxia-inducible factor-1
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