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BDNF-AS BDNF antisense RNA [ Homo sapiens (human) ]

Gene ID: 497258, updated on 11-Jun-2021

Summary

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Official Symbol
BDNF-ASprovided by HGNC
Official Full Name
BDNF antisense RNAprovided by HGNC
Primary source
HGNC:HGNC:20608
See related
Ensembl:ENSG00000245573 MIM:611468
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDNF; BDNFAS; BDNFOS; BDNF-AS1; ANTI-BDNF; NCRNA00049
Expression
Ubiquitous expression in brain (RPKM 3.5), thyroid (RPKM 1.9) and 23 other tissues See more
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Genomic context

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See BDNF-AS in Genome Data Viewer
Location:
11p14.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (27506852..27698171)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27528399..27719718)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene 7 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component Neighboring gene RNA, 5S ribosomal pseudogene 339 Neighboring gene microRNA 8087 Neighboring gene ribosomal protein S25 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 678 Neighboring gene Sharpr-MPRA regulatory region 8127 Neighboring gene brain derived neurotrophic factor Neighboring gene chromobox 3 pseudogene 1 Neighboring gene heat shock protein 90 alpha family class A member 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism. Marcos-Pasero H, et al. Clin Nutr, 2019 Dec. PMID 30501916
  2. LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma. Huang Q, et al. Biosci Rep, 2018 Dec 21. PMID 30352834, Free PMC Article
  3. Long noncoding RNA BDNF-AS is associated with clinical outcomes and has functional role in human prostate cancer. Li W, et al. Biomed Pharmacother, 2018 Jun. PMID 29710528
  4. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Modarresi F, et al. Nat Biotechnol, 2012 Mar 25. PMID 22446693, Free PMC Article
  5. LncRNA BDNF-AS suppresses colorectal cancer cell proliferation and migration by epigenetically repressing GSK-3β expression. Zhi H, et al. Cell Biochem Funct, 2019 Jul. PMID 31062382

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blood and tissue levels of lncRNAs in periodontitis.
    Title: Blood and tissue levels of lncRNAs in periodontitis.
  2. Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism.
    Title: Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism.
  3. WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors
    Title: In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors.
  4. These results provide evidence on polymorphism of BDNF / BDNFOS gene associated with Lumbar disc herniation risk in Chinese Han population.
    Title: Associations between Variants in BDNF/BDNFOS Gene and Lumbar Disc Herniation Risk among Han Chinese People.
  5. effect of lncRNA BDNF-AS in colorectal cancer (CRC) and revealed that lncRNA BDNF-AS expression is negatively correlated with the aggressive biological behaviour of CRC; further investigation demonstrated that lncRNA BDNF-AS functioned as a tumour suppressor in CRC progression by suppressing GSK-3beta expression through binding to EZH2 and H3K27me3 with the GSK-3beta promoter, shedding light on the diagnosis and therap...
    Title: LncRNA BDNF-AS suppresses colorectal cancer cell proliferation and migration by epigenetically repressing GSK-3β expression.
  6. The multivariate analysis suggested low expression of BDNF-AS was an independent unfavorable prognostic factor for overall survival in osteosarcoma patients
    Title: LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma.
  7. Upregulation of BDNF-AS is associated with a significant decrease in BDNF expression and increased recruitment of EZH2. The results suggest an important role for BDNF-AS in the regulation of synaptic plasticity via epigenetic reprogramming in the amygdala of alcohol use disorders subjects who began drinking during adolescence.
    Title: The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders.
  8. Downregulated BDNF-AS in prostate cancer patients could be a potential prognostic biomarker for predicating poor prognosis and survival.
    Title: Long noncoding RNA BDNF-AS is associated with clinical outcomes and has functional role in human prostate cancer.
  9. Study show that high concentrations of D-glucose induced significant apoptosis in human retinal pigment epithelial (RPE) cells in vitro. With treatment of 50 mM D-glucose, BDNF was markedly downregulated whereas BDNF-AS upregulated. Overall, results suggest that BDNF-AS, through inverse regulation of BDNF, might play a critical role in the process of D-glucose-induced apoptosis in diabetic retinopathy.
    Title: Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells.
  10. One variant in BDNF-AS was significantly associated with long-term visual memory.
    Title: BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Genome wide association study identifies KCNMA1 contributing to human obesity.
GeneReviews: Not available
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
GeneReviews: Not available
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
GeneReviews: Not available
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • BDNF antisense RNA (non-protein coding)
  • BDNF antisense RNA 1 (non-protein coding)
  • BDNF opposite strand (non-protein coding)
  • brain-derived neurotrophic factor opposite strand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002832.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (BT2B) represents the longest transcript.
    Source sequence(s)
    AC100771, AC104563, KF459669
    Related
    ENST00000499008.8

  2. NR_033312.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (BT1C) lacks an alternate exon and uses an alternate 3' splice pattern, compared to variant BT2B.
    Source sequence(s)
    AC100771, AC104563, KF459669
    Related
    ENST00000499568.3

  3. NR_033313.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (BT1A) lacks an alternate exon and uses an alternate 3' splice pattern, compared to variant BT2B.
    Source sequence(s)
    AC100771, AC104563, KF459669
    Related
    ENST00000502161.7

  4. NR_033314.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (BT2A) lacks an alternate exon, compared to variant BT2B.
    Source sequence(s)
    AC100771, AC104563, KF459669
    Related
    ENST00000651193.1

  5. NR_033315.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (BT1B) lacks two alternate exons and uses an alternate 3' splice pattern, compared to variant BT2B.
    Source sequence(s)
    AC100771, AC104563, KF459669
    Related
    ENST00000500662.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    27506852..27698171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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