LEPR leptin receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LEPRprovided by VGNC
Official Full Name: leptin receptorprovided by VGNC
Primary source: VGNC:VGNC:30843
See related: BGD:BT11244; EnsemblRapid:ENSBTAG00070001796
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: Ob-R; Ob-RM
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (79733479..79837823, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Detection of polymorphisms in the bovine leptin receptor gene affects fat deposition in two Chinese beef cattle breeds.
Title: Detection of polymorphisms in the bovine leptin receptor gene affects fat deposition in two Chinese beef cattle breeds.
Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively.
Title: Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation.
I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression
Title: Copy number variations at LEPR gene locus associated with gene expression and phenotypic traits in Chinese cattle.
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
Title: Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
Title: Genetic polymorphisms of leptin and leptin receptor genes in relation with production and reproduction traits in cattle.
The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
Title: Effect of polymorphisms in the leptin, leptin receptor and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes and genetic polymorphism of milk proteins on bovine milk composition.
The leptin and receptor gene markers would be useful for marker-assisted selection.
Title: Association of single nucleotide polymorphisms in the bovine leptin and leptin receptor genes with growth and ultrasound carcass traits in Nellore cattle.
The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.
Title: Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows.
The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.
Title: Leptin receptor mRNA in bull ejaculated spermatozoa.
the possible involvement of locally produced leptin/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.
Title: The expression of leptin and its receptor during different physiological stages in the bovine ovary.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

MARC_46107-46108:1108421350:1 (e-PCR)
- UniSTS:471639

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leptin receptor

Names: OB receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012285.2 → NP_001012285.2 leptin receptor

See identical proteins and their annotated locations for NP_001012285.2

Status: PROVISIONAL

Source sequence(s)

AB199589

UniProtKB/TrEMBL

A0A3Q1MPM8, Q5KQU5

Related

ENSBTAP00070002331.1, ENSBTAT00070004164.1

Conserved Domains (3) summary

smart00060
Location:741 → 820

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 330

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:333 → 420

Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

79733479..79837823 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024985494.2 → XP_024841262.1 leptin receptor isoform X2

UniProtKB/TrEMBL

A0A3Q1MPM8, F1N1E9

Conserved Domains (3) summary

smart00060
Location:741 → 820

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 330

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:333 → 420

Lep_receptor_Ig; Ig-like C2-type domain
XM_010803431.4 → XP_010801733.2 leptin receptor isoform X1

UniProtKB/TrEMBL

A0AAA9TX24, Q59HQ0

Related

ENSBTAP00070002327.1, ENSBTAT00070004157.1

Conserved Domains (3) summary

smart00060
Location:741 → 820

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 330

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:333 → 420

Lep_receptor_Ig; Ig-like C2-type domain