U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plcz1 phospholipase C, zeta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497197, updated on 2-Nov-2024

Summary

Symbol
Plcz1provided by RGD
Full Name
phospholipase C, zeta 1provided by RGD
Primary source
RGD:1359567
See related
EnsemblRapid:ENSRNOG00000008514 AllianceGenome:RGD:1359567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Located in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (phospholipase C zeta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 270.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plcz1 in Genome Data Viewer
Location:
4q44
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (174604281..174660368, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (172873110..172929191, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (174125072..174181524, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RERG like Neighboring gene uncharacterized LOC120102423 Neighboring gene phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma Neighboring gene capping actin protein of muscle Z-line subunit alpha 3 Neighboring gene uncharacterized LOC108350783

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
NOT located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in pronucleus ISO
Inferred from Sequence Orthology
more info
 
located_in sperm head ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
PLC-zeta-1
phosphoinositide phospholipase C-zeta-1
NP_001012234.1
XP_006237662.1
XP_017448260.1
XP_038963974.1
XP_038963975.1
XP_038963976.1
XP_038963978.1
XP_038963979.1
XP_038963980.1
XP_063142523.1
XP_063142524.1
XP_063142525.1
XP_063142526.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012234.2NP_001012234.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

    See identical proteins and their annotated locations for NP_001012234.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5FX52
    UniProtKB/TrEMBL
    A6IMM6
    Related
    ENSRNOP00000011376.4, ENSRNOT00000011376.6
    Conserved Domains (2) summary
    PLN02952
    Location:78640
    PLN02952; phosphoinositide phospholipase C
    cl14615
    Location:161488
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    174604281..174660368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286453.1XP_063142523.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FX52
    UniProtKB/TrEMBL
    A6IMM6
  2. XM_063286454.1XP_063142524.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FX52
    UniProtKB/TrEMBL
    A6IMM6
  3. XM_063286456.1XP_063142526.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

  4. XM_039108048.2XP_038963976.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  5. XM_039108050.2XP_038963978.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  6. XM_006237600.5XP_006237662.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    Conserved Domains (4) summary
    cd00275
    Location:494619
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02952
    Location:54616
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:55137
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:137464
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  7. XM_039108047.2XP_038963975.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  8. XM_063286455.1XP_063142525.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

  9. XM_039108051.2XP_038963979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

    Conserved Domains (2) summary
    PLN02952
    Location:23417
    PLN02952; phosphoinositide phospholipase C
    cl14615
    Location:23265
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  10. XM_039108046.2XP_038963974.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    Conserved Domains (2) summary
    PLN02230
    Location:1529
    PLN02230; phosphoinositide phospholipase C 4
    cl14615
    Location:52379
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  11. XM_017592771.3XP_017448260.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    Conserved Domains (4) summary
    cd00275
    Location:494619
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02952
    Location:54616
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:55137
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:137464
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  12. XM_039108052.2XP_038963980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    cd00275
    Location:252377
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1222
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RNA

  1. XR_010065686.1 RNA Sequence