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Eng endoglin [ Rattus norvegicus (Norway rat) ]

Gene ID: 497010, updated on 10-Jul-2024

Summary

Symbol
Engprovided by RGD
Full Name
endoglinprovided by RGD
Primary source
RGD:1593188
See related
EnsemblRapid:ENSRNOG00000050190 AllianceGenome:RGD:1593188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 746.2), Heart (RPKM 349.5) and 7 other tissues See more
Orthologs
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Genomic context

See Eng in Genome Data Viewer
Location:
3p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36332190..36370324)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15934566..15972618)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11679530..11717486)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene adenylate kinase 1 Neighboring gene folylpolyglutamate synthase Neighboring gene cyclin-dependent kinase 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC124909

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to BMP binding ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables galactose binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activator activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transforming growth factor beta receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular canal morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in cardiac jelly development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell migration involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in central nervous system vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in endocardial cushion to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in smooth muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular associated smooth muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in venous blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endothelial microparticle ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010968.3NP_001010968.1  endoglin precursor

    See identical proteins and their annotated locations for NP_001010968.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6GL08, A0A9K3Y7N3, M0RBA8, Q6Q3E8
    Related
    ENSRNOP00000066838.4, ENSRNOT00000074562.5
    Conserved Domains (1) summary
    smart00241
    Location:359499
    ZP; Zona pellucida (ZP) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36332190..36370324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284324.1XP_063140394.1  endoglin isoform X1

    UniProtKB/TrEMBL
    A0A8I6GL08, Q3KR75