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Eng endoglin [ Rattus norvegicus (Norway rat) ]

Gene ID: 497010, updated on 22-May-2018
Symbol
Engprovided by RGD
Full Name
endoglinprovided by RGD
Primary source
RGD:1593188
See related
Ensembl:ENSRNOG00000050190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 746.2), Heart (RPKM 349.5) and 7 other tissues See more
Orthologs
See Eng in Genome Data Viewer
Location:
3p11
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11679530..11717486)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (17021673..17058548)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene adenylate kinase 1 Neighboring gene folylpolyglutamate synthase Neighboring gene uncharacterized LOC103691767

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...

Markers

Homology

Clone Names

  • MGC124909

Gene Ontology Provided by RGD

Function Evidence Code Pubs
BMP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to BMP binding ISO
Inferred from Sequence Orthology
more info
 
galactose binding IEA
Inferred from Electronic Annotation
more info
 
galactose binding ISO
Inferred from Sequence Orthology
more info
 
glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
 
glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor, cytoplasmic mediator activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor, cytoplasmic mediator activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
type I transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 
type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrial cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrioventricular canal morphogenesis ISO
Inferred from Sequence Orthology
more info
 
bone development IEP
Inferred from Expression Pattern
more info
PubMed 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT cardiac jelly development ISO
Inferred from Sequence Orthology
more info
 
cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
cell motility ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
central nervous system vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
chronological cell aging ISO
Inferred from Sequence Orthology
more info
 
detection of hypoxia ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT endocardial cushion to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart looping ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to corticosteroid IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
PubMed 
smooth muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
NOT sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NOT transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle cell development ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
venous blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
endothelial microparticle ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010968.2NP_001010968.1  endoglin precursor

    See identical proteins and their annotated locations for NP_001010968.1

    Status: VALIDATED

    Source sequence(s)
    AY562420, BC105860
    UniProtKB/TrEMBL
    Q3KR75, Q6Q3E8
    Related
    ENSRNOP00000066355.2, ENSRNOT00000071801.2
    Conserved Domains (1) summary
    smart00241
    Location:359499
    ZP; Zona pellucida (ZP) domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    11679530..11717486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591971.1XP_017447460.1  endoglin isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    10675660..10713537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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