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OGN osteoglycin [ Homo sapiens (human) ]

Gene ID: 4969, updated on 1-Aug-2020

Summary

Official Symbol
OGNprovided by HGNC
Official Full Name
osteoglycinprovided by HGNC
Primary source
HGNC:HGNC:8126
See related
Ensembl:ENSG00000106809 MIM:602383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OG; OIF; SLRR3A
Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues See more
Orthologs

Genomic context

See OGN in Genome Data Viewer
Location:
9q22.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (92383268..92404699, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95146249..95166976, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nucleolar protein 8 Neighboring gene chromosome 16 open reading frame 70 pseudogene Neighboring gene centromere protein P Neighboring gene osteomodulin Neighboring gene asporin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586P2421

General protein information

Preferred Names
mimecan
Names
corneal keratan sulfate proteoglycan
mimecan proteoglycan
osteoinductive factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014057.5NP_054776.1  mimecan isoform 2 precursor

    See identical proteins and their annotated locations for NP_054776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (2).
    Source sequence(s)
    AF086912, AF100758, AK295433, AL137848, BM679549
    Consensus CDS
    CCDS6695.1
    UniProtKB/Swiss-Prot
    P20774
    UniProtKB/TrEMBL
    A8K0R3, B4DI63, Q7Z532
    Related
    ENSP00000364711.5, ENST00000375561.10
    Conserved Domains (2) summary
    sd00033
    Location:123144
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143225
    LRR_8; Leucine rich repeat
  2. NM_024416.4NP_077727.3  mimecan isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (1) has a longer N-terminus and lacks a predicted signal peptide compared to isoform 2.
    Source sequence(s)
    AF086912, AK295433, AL137848, BC095443, BG772245, BM679549
    UniProtKB/Swiss-Prot
    P20774
    UniProtKB/TrEMBL
    B4DI63, Q7Z532
    Conserved Domains (3) summary
    sd00033
    Location:181202
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:181218
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:201283
    LRR_8; Leucine rich repeat
  3. NM_033014.3NP_148935.1  mimecan isoform 2 precursor

    See identical proteins and their annotated locations for NP_148935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (2). Both variants 1 and 3 encode the same isoform (2).
    Source sequence(s)
    AK295433, AL137848, BC095443, BG772245, BM679549, CB268982
    Consensus CDS
    CCDS6695.1
    UniProtKB/Swiss-Prot
    P20774
    UniProtKB/TrEMBL
    A8K0R3, B4DI63
    Related
    ENSP00000262551.4, ENST00000262551.8
    Conserved Domains (2) summary
    sd00033
    Location:123144
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143225
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    92383268..92404699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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