ada adenosine deaminase [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: adaprovided by Xenbase
Official Full Name: adenosine deaminaseprovided by Xenbase
Primary source: Xenbase:XB-GENE-950501
See related: Ensembl:ENSXETG00000003459 AllianceGenome:Xenbase:XB-GENE-950501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: xada
Summary: Predicted to enable adenosine deaminase activity and zinc ion binding activity. Predicted to be involved in several processes, including hypoxanthine salvage; negative regulation of adenosine receptor signaling pathway; and purine ribonucleoside metabolic process. Predicted to act upstream of or within nucleotide metabolic process and purine ribonucleoside monophosphate biosynthetic process. Predicted to be located in several cellular components, including anchoring junction; cytoplasmic vesicle lumen; and lysosome. Predicted to be active in cytosol and external side of plasma membrane. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: chromosome: 10

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	10	NC_030686.2 (37910108..37995335)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	10	NC_030686.1 (29663028..29705233)

Chromosome 10 - NC_030686.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 2'-deoxyadenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenosine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hypoxanthine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in inosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inosine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle lumen	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine deaminase

Names: adenosine aminohydrolase

NP_001011025.1

EC 3.5.4.4

XP_031749914.1

EC 3.5.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011025.1 → NP_001011025.1 adenosine deaminase

See identical proteins and their annotated locations for NP_001011025.1

Status: PROVISIONAL

Source sequence(s)

BC082820

UniProtKB/Swiss-Prot

Q63ZU0

UniProtKB/TrEMBL

A0A803K5M5

Related

ENSXETP00000105075.1, ENSXETT00000105752.1

Conserved Domains (1) summary

cd01320
Location:7 → 346

ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030686.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

37910108..37995335

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031894054.1 → XP_031749914.1 adenosine deaminase isoform X1

UniProtKB/TrEMBL

A0A803K5M5, F6RPM0

Related

ENSXETP00000007489.5, ENSXETT00000007489.5

Conserved Domains (1) summary

cd01320
Location:17 → 353

ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...