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fadd.S Fas associated via death domain S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 496403, updated on 5-Jul-2025
Official Symbol
fadd.S
Official Full Name
Fas associated via death domain S homeolog
Primary source
Xenbase:XB-GENE-6251981
Locus tag
XELAEV_18024459mg
See related
EnsemblRapid:ENSXLAG00005022091 AllianceGenome:Xenbase:XB-GENE-6251981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fadd; mort1; xfadd; adaptor
Summary
Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Human ortholog(s) of this gene implicated in immunodeficiency 90 and leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Jul 2025]
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See fadd.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
2
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (13529219..13531784)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (13151732..13154297)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121393179 Neighboring gene uncharacterized LOC108715237 Neighboring gene cyclin D1 S homeolog Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 S homeolog Neighboring gene serine/threonine-protein kinase mig-15-like Neighboring gene traf2 and NCK-interacting protein kinase-like Neighboring gene astacin-like metallo-endopeptidase 2 gene a S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity. Sakamaki K, et al. Genes Cells, 2004 Dec. PMID 15569156
  2. Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB. Ishizawa YH, et al. Biol Cell, 2006 Aug. PMID 16597320
  3. Multiple functions of FADD in apoptosis, NF-κB-related signaling, and heart development in Xenopus embryos. Sakamaki K, et al. Genes Cells, 2012 Nov. PMID 23025414
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FADD has multiple functions in embryos; it plays a part in the regulation of NF-kappaB activation and heart formation, in addition to apoptosis.
    Title: Multiple functions of FADD in apoptosis, NF-κB-related signaling, and heart development in Xenopus embryos.
  2. The FADD protein shows evolutionary conservation.
    Title: The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity.
  3. Interaction of xFADD and xRIP1 induced synergistic activation of JNK and NF-kappaB.
    Title: Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Fas associated via death domain S homeolog
Names
Fas (TNFRSF6)-associated via death domain
Fas-associating death domain-containing protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095548.1 → NP_001089017.1  Fas associated via death domain S homeolog

    See identical proteins and their annotated locations for NP_001089017.1

    Status: PROVISIONAL

    Source sequence(s)
    AY521029
    UniProtKB/TrEMBL
    A0A974D043, Q5J2J1
    Related
    ENSXLAP00005064880.1, ENSXLAT00005066395.1
    Conserved Domains (2) summary
    cd08306
    Location:99 → 183
    Death_FADD; Fas-associated Death Domain protein-protein interaction domain
    cd08336
    Location:1 → 81
    DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    13529219..13531784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials