K8 K8 [Human gammaherpesvirus 8] - Gene

Summary

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Gene symbol: K8
Gene description: K8
Locus tag: HHV8GK18_gp54
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:: NC_009333.1 (74949..76818)

NC_009333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data conclusively shows that K-RTA/K8 proteins specifically bind to these motifs on the host/viral genomes to modulate transcription of host/viral genes during KSHV lytic reactivation.
Title: KSHV lytic proteins K-RTA and K8 bind to cellular and viral chromatin to modulate gene expression.
ORF57 and K-bZIP coregulate viral gene expression during lytic infection.
Title: Chromatin immunoprecipitation and microarray analysis suggest functional cooperation between Kaposi's Sarcoma-associated herpesvirus ORF57 and K-bZIP.
Data show that leucine zipper domain, not the SUMOylation of K-bZIP, is required for K-bZIP to interact with HDAC1/2 and with some KSHV lytic gene promoters and that these interactions are important for human herpesvirus-8 to replicate.
Title: Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication.
Inhibition of human JMJD2A by Kaposi's sarcoma-associated herpesvirus bZIP is likely due to a physical interaction which blocks substrate accessibility.
Title: Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor.
K8 is not absolutely required for KSHV viral lytic DNA replication and viral propagation.
Title: Functional characterization of Kaposi's sarcoma-associated herpesvirus open reading frame K8 by bacterial artificial chromosome-based mutagenesis.
These data suggest that the interaction of LANA with K-bZIP modulates lytic and latent replication and that K-bZIP facilitates lytic DNA replication and modulates the switch from the latent phase of the virus.
Title: Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis.
Deletion of the basic amino acid region (BR) or LZ domain did not affect the ability of K-bZIP to bind to K-Rta indicating that either region contributes to heterodimerization with K-Rta.
Title: Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication.
K-bZIP prevents IRF-3 from binding to the IFN-beta promoter and precludes the formation of the enhanceosome, required for maximal ifn-beta gene transcription
Title: Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.
K-bZIP may serve to augment or facilitate the interaction of K-Rta with oriLyt.
Title: Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotype.
K8 undergoes 3 splicings to produce K-bZIP (237 aa)
Title: Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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regulatory

Loc: 76813-76818 regulatory_class = polyA_signal_sequence

variation

Loc: 76723-76796 replace =

General protein information

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Preferred Names: K8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_009333.1 Reference assembly

Range

74949..76818

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_001129403.1 K8 [Human gammaherpesvirus 8]

See identical proteins and their annotated locations for YP_001129403.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q2HR82

UniProtKB/TrEMBL

E5LBX3

Conserved Domains (1) summary

pfam07188
Location:1 → 238

KSHV_K8; Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein