ppara.L peroxisome proliferator activated receptor alpha L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ppara.L
Official Full Name: peroxisome proliferator activated receptor alpha L homeolog
Primary source: Xenbase:XB-GENE-480233
Locus tag: XELAEV_18016654mg
See related: EnsemblRapid:ENSXLAG00005009056 AllianceGenome:Xenbase:XB-GENE-480233
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nr1c1; ppara; xppara; ppara.S; PPARalpha; xPPARalpha
Summary: Predicted to enable several functions, including nuclear receptor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 3L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (2649938..2670888, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (2380897..2401631, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694874.1 (23039..23306, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxisome proliferation could lead to increased susceptibility to bacterial pathogens in tobacco by altering the redox balance of the plant and the expression pattern of key defense signaling pathway genes.
Title: Transformed tobacco (Nicotiana tabacum) plants over-expressing a peroxisome proliferator-activated receptor gene from Xenopus laevis (xPPARα) show increased susceptibility to infection by virulent Pseudomonas syringae pathogens.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisome proliferator activated receptor alpha L homeolog

Names: peroxisome proliferator-activated receptor alpha S homeolog; xPPAR alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095362.1 → NP_001088831.1 peroxisome proliferator activated receptor alpha L homeolog

See identical proteins and their annotated locations for NP_001088831.1

Status: PROVISIONAL

Source sequence(s)

BC087622

UniProtKB/Swiss-Prot

P37232

UniProtKB/TrEMBL

Q5PPL6

Related

ENSXLAP00005026369.1, ENSXLAT00005027101.1

Conserved Domains (2) summary

cd06932
Location:203 → 468

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:103 → 186

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

2649938..2670888 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041585212.1 → XP_041441146.1 peroxisome proliferator activated receptor alpha L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MID8

Conserved Domains (2) summary

cd06932
Location:103 → 368

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cl02596
Location:71 → 86

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers