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ATP4B ATPase H+/K+ transporting subunit beta [ Homo sapiens (human) ]

Gene ID: 496, updated on 24-Nov-2020

Summary

Official Symbol
ATP4Bprovided by HGNC
Official Full Name
ATPase H+/K+ transporting subunit betaprovided by HGNC
Primary source
HGNC:HGNC:820
See related
Ensembl:ENSG00000186009 MIM:137217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP6B
Summary
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward stomach (RPKM 286.6) See more
Orthologs

Genomic context

See ATP4B in Genome Data Viewer
Location:
13q34
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (113648804..113658198, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114303119..114312513, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene transcription factor Dp-1 Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene transmembrane protein 255B Neighboring gene GAS6 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
potassium:proton exchanging ATPase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
pH reduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane TAS
Traceable Author Statement
more info
 
sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium-transporting ATPase subunit beta
Names
ATPase H+/K+ transporting beta subunit
ATPase, H+/K+ exchanging, beta polypeptide
ATPase, H+/K+ transporting, beta polypeptide
gastric H(+)/K(+) ATPase subunit beta
gastric H+/K+ ATPase beta subunit
gastric hydrogen-potassium ATPase, beta
potassium-transporting ATPase beta chain
proton pump beta chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000705.4NP_000696.1  potassium-transporting ATPase subunit beta

    See identical proteins and their annotated locations for NP_000696.1

    Status: REVIEWED

    Source sequence(s)
    BC029059, BI764514, BX100065, DA964061
    Consensus CDS
    CCDS9539.1
    UniProtKB/Swiss-Prot
    P51164
    Related
    ENSP00000334216.3, ENST00000335288.5
    Conserved Domains (1) summary
    TIGR01107
    Location:2291
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    113648804..113658198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160011.1 Reference GRCh38.p13 PATCHES

    Range
    1..9021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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