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ODF1 outer dense fiber of sperm tails 1 [ Homo sapiens (human) ]

Gene ID: 4956, updated on 21-Dec-2019

Summary

Official Symbol
ODF1provided by HGNC
Official Full Name
outer dense fiber of sperm tails 1provided by HGNC
Primary source
HGNC:HGNC:8113
See related
Ensembl:ENSG00000155087 MIM:182878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODF; RT7; ODF2; ODFP; SODF; CT133; ODF27; ODFPG; HSPB10; ODFPGA; ODFPGB
Summary
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 125.7) See more
Orthologs

Genomic context

See ODF1 in Genome Data Viewer
Location:
8q22.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (102551589..102561018)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103563848..103573245)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1224, pseudogene Neighboring gene uncharacterized LOC105375684 Neighboring gene POU class 5 homeobox 1 pseudogene 2 Neighboring gene Kruppel like factor 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129928, MGC129929

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus HDA PubMed 
outer dense fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
outer dense fiber protein 1
Names
cancer/testis antigen 133
heat shock protein beta-10
outer dense fiber of sperm tails, 27-kD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028006.1 RefSeqGene

    Range
    4970..14399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024410.4NP_077721.2  outer dense fiber protein 1

    See identical proteins and their annotated locations for NP_077721.2

    Status: REVIEWED

    Source sequence(s)
    AP002851, AP002852, BG214987, DB457574
    Consensus CDS
    CCDS6293.1
    UniProtKB/Swiss-Prot
    Q14990
    Related
    ENSP00000285402.3, ENST00000285402.4
    Conserved Domains (1) summary
    cd06482
    Location:116202
    ACD_HspB10; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    102551589..102561018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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