prkaa1.L protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: prkaa1.L
Official Full Name: protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog
Primary source: Xenbase:XB-GENE-946198
Locus tag: XELAEV_18008336mg
See related: EnsemblRapid:ENSXLAG00005023449 AllianceGenome:Xenbase:XB-GENE-946198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ampk; ampka1; prkaa1
Summary: Predicted to enable AMP-activated protein kinase activity; ATP binding activity; and [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity. Predicted to act upstream of or within fatty acid biosynthetic process; rhythmic process; and sterol biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 1L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (213312323..213346854)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (200111162..200145724)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
Title: Down-regulation of the Na+-coupled phosphate transporter NaPi-IIa by AMP-activated protein kinase.
NDPK-A exists in a functional cellular complex with AMPK and CFTR in airway epithelia, and NDPK-A catalytic function is required for the AMPK-dependent regulation of CFTR
Title: Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094957.1 → NP_001088426.1 protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog

See identical proteins and their annotated locations for NP_001088426.1

Status: PROVISIONAL

Source sequence(s)

BC084741

UniProtKB/TrEMBL

A0A974I600, Q5U5E3

Related

ENSXLAP00005069403.1, ENSXLAT00005070937.1

Conserved Domains (4) summary

cd12199
Location:405 → 558

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

smart00220
Location:27 → 279

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14403
Location:296 → 360

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cd14079
Location:24 → 279

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase