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OCM2 oncomodulin 2 [ Homo sapiens (human) ]

Gene ID: 4951, updated on 23-Nov-2021

Summary

Official Symbol
OCM2provided by HGNC
Official Full Name
oncomodulin 2provided by HGNC
Primary source
HGNC:HGNC:34396
See related
Ensembl:ENSG00000135175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OM; OCM
Summary
This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. [provided by RefSeq, Jul 2008]
Annotation information
Note: There are two oncomodulin-like loci on chromosome 7 (GeneIDs 4951 and 654231). The nomenclature for the p and q arm locations was modified to agree with reports (including PMID: 1559707) that place the OCM gene on the p arm. [18 Jun 2007]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OCM2 in Genome Data Viewer
Location:
7q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (97984687..97990196, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97614012..97619416, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CZ1P-ASNS readthrough Neighboring gene CCZ1P-OR7E38P readthrough Neighboring gene olfactory receptor family 7 subfamily E member 38 pseudogene Neighboring gene CCZ1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 478, pseudogene Neighboring gene lemur tyrosine kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative oncomodulin-2
Names
parvalbumin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006188.4NP_006179.2  putative oncomodulin-2

    See identical proteins and their annotated locations for NP_006179.2

    Status: VALIDATED

    Source sequence(s)
    AC004967
    Consensus CDS
    CCDS5653.1
    UniProtKB/Swiss-Prot
    P0CE71
    Related
    ENSP00000257627.4, ENST00000257627.4
    Conserved Domains (1) summary
    cd16255
    Location:9109
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    97984687..97990196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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