U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

irf5.L interferon regulatory factor 5 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 494760, updated on 5-Sep-2025
Official Symbol
irf5.L
Official Full Name
interferon regulatory factor 5 L homeolog
Primary source
Xenbase:XB-GENE-998629
Locus tag
XELAEV_18017919mg
See related
EnsemblRapid:ENSXLAG00005032969 AllianceGenome:Xenbase:XB-GENE-998629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
irf5
Summary
Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to act upstream of or within positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5). [provided by Alliance of Genome Resources, Apr 2025]
NEW
Try the new Gene table
Try the new Transcript table
See irf5.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (93311362..93334580)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (77988217..78011931)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene kielin/chordin-like protein L homeolog Neighboring gene cadherin-related family member 5-like Neighboring gene uncharacterized LOC108711247 Neighboring gene transportin 3 L homeolog Neighboring gene RNA polymerase I subunit H L homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
interferon regulatory factor 5 L homeolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094596.1 → NP_001088065.1  interferon regulatory factor 5 L homeolog

    See identical proteins and their annotated locations for NP_001088065.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082862
    UniProtKB/TrEMBL
    A0A974HTB3, Q63ZP8
    Related
    ENSXLAP00005098750.1, ENSXLAT00005100587.1
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:267 → 449
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    93311362..93334580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018251110.2 → XP_018106599.1  interferon regulatory factor 5 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UNU4
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:268 → 450
    IRF-3; Interferon-regulatory factor 3

  2. XM_018251109.2 → XP_018106598.1  interferon regulatory factor 5 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UNU4
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:268 → 450
    IRF-3; Interferon-regulatory factor 3

  3. XM_018251111.2 → XP_018106600.1  interferon regulatory factor 5 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A974HTB3, Q63ZP8

  4. XM_041585181.1 → XP_041441115.1  interferon regulatory factor 5 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UNU4
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:268 → 450
    IRF-3; Interferon-regulatory factor 3

  5. XM_041585180.1 → XP_041441114.1  interferon regulatory factor 5 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UNU4
    Related
    ENSXLAP00005098710.1, ENSXLAT00005100545.1
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:268 → 450
    IRF-3; Interferon-regulatory factor 3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials