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WEE2 WEE2 oocyte meiosis inhibiting kinase [ Homo sapiens (human) ]

Gene ID: 494551, updated on 3-Feb-2021

Summary

Official Symbol
WEE2provided by HGNC
Official Full Name
WEE2 oocyte meiosis inhibiting kinaseprovided by HGNC
Primary source
HGNC:HGNC:19684
See related
Ensembl:ENSG00000214102 MIM:614084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OOMD5; WEE1B
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See WEE2 in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141708353..141731271)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141408153..141431071)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene AGK divergent transcript Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11 Neighboring gene WEE2 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 82, pseudogene Neighboring gene single stranded DNA binding protein 1 Neighboring gene taste 2 receptor member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with disordered eating.
GeneReviews: Not available
OOCYTE MATURATION DEFECT 5
MedGen: CN257793 OMIM: 617996 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16107

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
female meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
female pronucleus assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of fertilization IEA
Inferred from Electronic Annotation
more info
 
regulation of meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
wee1-like protein kinase 2
Names
WEE1 homolog 2
wee1-like protein kinase 1B
wee1B kinase
NP_001099028.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105558.1NP_001099028.1  wee1-like protein kinase 2

    See identical proteins and their annotated locations for NP_001099028.1

    Status: VALIDATED

    Source sequence(s)
    AC004918, AK131218, BG402079, BM790836
    Consensus CDS
    CCDS43660.1
    UniProtKB/Swiss-Prot
    P0C1S8
    Related
    ENSP00000380675.2, ENST00000397541.6
    Conserved Domains (2) summary
    cd14139
    Location:211485
    PTKc_Wee1b; Catalytic domain of the Protein Tyrosine Kinase, Wee1b
    pfam00069
    Location:212480
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    141708353..141731271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315922.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    80953..103871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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