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Apcdd1 adenomatosis polyposis coli down-regulated 1 [ Mus musculus (house mouse) ]

Gene ID: 494504, updated on 7-May-2024

Summary

Official Symbol
Apcdd1provided by MGI
Official Full Name
adenomatosis polyposis coli down-regulated 1provided by MGI
Primary source
MGI:MGI:3513977
See related
Ensembl:ENSMUSG00000071847 AllianceGenome:MGI:3513977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drapc1; EIG180
Summary
Predicted to enable Wnt-protein binding activity and identical protein binding activity. Involved in regulation of odontogenesis of dentin-containing tooth. Acts upstream of or within astrocyte cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; ear; and reproductive system. Human ortholog(s) of this gene implicated in hypotrichosis 1. Orthologous to human APCDD1 (APC down-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 94.0), limb E14.5 (RPKM 52.5) and 15 other tissues See more
Orthologs
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Genomic context

See Apcdd1 in Genome Data Viewer
Location:
18 E1; 18 35.95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63055398..63086886)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62922327..62953815)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598 Neighboring gene STARR-seq mESC enhancer starr_44779 Neighboring gene STARR-seq mESC enhancer starr_44780 Neighboring gene predicted gene, 41752 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene piezo-type mechanosensitive ion channel component 2 Neighboring gene predicted gene, 36651

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein APCDD1
Names
adenomatosis polyposis coli down-regulated 1 protein homolog
ethanol induced gene product EIG180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133237.4NP_573500.2  protein APCDD1 precursor

    See identical proteins and their annotated locations for NP_573500.2

    Status: VALIDATED

    Source sequence(s)
    AC130204
    Consensus CDS
    CCDS37843.1
    UniProtKB/Swiss-Prot
    B2RUN4, Q3TA99, Q3U128
    Related
    ENSMUSP00000157539.2, ENSMUST00000236135.2
    Conserved Domains (1) summary
    pfam14921
    Location:51282
    APCDDC; Adenomatosis polyposis coli down-regulated 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    63055398..63086886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161200.1XP_036017093.1  protein APCDD1 isoform X1

    Conserved Domains (1) summary
    pfam14921
    Location:1192
    APCDDC; Adenomatosis polyposis coli down-regulated 1