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RNF165 ring finger protein 165 [ Homo sapiens (human) ]

Gene ID: 494470, updated on 1-Jun-2020

Summary

Official Symbol
RNF165provided by HGNC
Official Full Name
ring finger protein 165provided by HGNC
Primary source
HGNC:HGNC:31696
See related
Ensembl:ENSG00000141622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARKL2; Ark2C; RNF111L2
Summary
Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.7), spleen (RPKM 1.6) and 12 other tissues See more
Orthologs

Genomic context

See RNF165 in Genome Data Viewer
Location:
18q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (46334018..46463145)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (43906772..44041159)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1278, pseudogene Neighboring gene HAUS augmin like complex subunit 1 Neighboring gene chromosome 18 open reading frame 25 Neighboring gene uncharacterized LOC105372095 Neighboring gene lipoxygenase homology domains 1 Neighboring gene uncharacterized LOC105372096

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
innervation IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism aging IEA
Inferred from Electronic Annotation
more info
 
muscle structure development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF165
NP_001243687.1
NP_689683.2
XP_011524318.1
XP_016881277.1
XP_024306959.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256758.1NP_001243687.1  E3 ubiquitin-protein ligase RNF165 isoform 2

    See identical proteins and their annotated locations for NP_001243687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC018931, AK122819
    Consensus CDS
    CCDS58621.1
    UniProtKB/Swiss-Prot
    Q6ZSG1
    Related
    ENSP00000444285.1, ENST00000543885.2
    Conserved Domains (1) summary
    cd16474
    Location:100145
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
  2. NM_152470.3NP_689683.2  E3 ubiquitin-protein ligase RNF165 isoform 1

    See identical proteins and their annotated locations for NP_689683.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC015959, AC018931, AK122819, AK127467, AW160725, BM680948
    Consensus CDS
    CCDS32823.1
    UniProtKB/Swiss-Prot
    Q6ZSG1
    UniProtKB/TrEMBL
    A0A059NXK6
    Related
    ENSP00000269439.6, ENST00000269439.12
    Conserved Domains (1) summary
    cd16474
    Location:292337
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins

RNA

  1. NR_046357.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and uses an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC015959, DA077941

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    46334018..46463145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526016.3XP_011524318.1  E3 ubiquitin-protein ligase RNF165 isoform X1

    See identical proteins and their annotated locations for XP_011524318.1

    Conserved Domains (1) summary
    cd16474
    Location:260305
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
  2. XM_017025788.2XP_016881277.1  E3 ubiquitin-protein ligase RNF165 isoform X2

  3. XM_024451191.1XP_024306959.1  E3 ubiquitin-protein ligase RNF165 isoform X3

    Conserved Domains (1) summary
    cd16474
    Location:100145
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
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