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MIR424 microRNA 424 [ Homo sapiens (human) ]

Gene ID: 494336, updated on 25-Nov-2019

Summary

Official Symbol
MIR424provided by HGNC
Official Full Name
microRNA 424provided by HGNC
Primary source
HGNC:HGNC:31881
See related
Ensembl:ENSG00000284231 MIM:300682; miRBase:MI0001446
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR322; MIRN424; mir-424; miRNA424; hsa-mir-424
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR424 in Genome Data Viewer
Location:
Xq26.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (134546614..134546711, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133680644..133680741, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MIR503 host gene Neighboring gene long intergenic non-protein coding RNA 629 Neighboring gene microRNA 542 Neighboring gene microRNA 503 Neighboring gene placenta enriched 1 Neighboring gene ribosomal protein L21 pseudogene 133

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of G0 to G1 transition IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of store-operated calcium entry ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular associated smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of vascular smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of aortic smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029946.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC004383
    Related
    ENST00000362227.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    134546614..134546711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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