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MIR424 microRNA 424 [ Homo sapiens (human) ]

Gene ID: 494336, updated on 30-Oct-2022

Summary

Official Symbol
MIR424provided by HGNC
Official Full Name
microRNA 424provided by HGNC
Primary source
HGNC:HGNC:31881
See related
Ensembl:ENSG00000284231 MIM:300682; miRBase:MI0001446; AllianceGenome:HGNC:31881
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR322; MIRN424; mir-424; miRNA424; hsa-mir-424
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR424 in Genome Data Viewer
Location:
Xq26.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (134546614..134546711, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (132871802..132871899, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133680644..133680741, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MIR503 host gene Neighboring gene long intergenic non-protein coding RNA 629 Neighboring gene microRNA 542 Neighboring gene microRNA 503 Neighboring gene placenta enriched 1 Neighboring gene ribosomal protein L21 pseudogene 133

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of G0 to G1 transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of store-operated calcium entry ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of aortic smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029946.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC004383
    Related
    ENST00000362227.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    134546614..134546711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    132871802..132871899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)