U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

unc5b unc-5 netrin receptor B [ Danio rerio (zebrafish) ]

Gene ID: 494130, updated on 9-Sep-2025
Official Symbol
unc5bprovided by ZNC
Official Full Name
unc-5 netrin receptor Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041213-1
See related
Ensembl:ENSDARG00000033327 AllianceGenome:ZFIN:ZDB-GENE-041213-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
unc5h2; sb:eu495
Summary
Predicted to enable netrin receptor activity. Acts upstream of or within branching involved in blood vessel morphogenesis and negative regulation of angiogenesis. Predicted to be located in plasma membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; pectoral fin bud; and trunk vasculature. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See unc5b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (32516448..32614543)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (29128153..29226334)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene lymphocyte antigen 6 family member pge Neighboring gene myoferlin like Neighboring gene poly (ADP-ribose) glycohydrolase a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. Kaur S, et al. Gene Expr, 2007. PMID 17708418, Free PMC Article
  2. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. Pradella D, et al. Nat Commun, 2021 Aug 11. PMID 34381052, Free PMC Article
  3. A rapid and scalable method for selecting recombinant mouse monoclonal antibodies. Crosnier C, et al. BMC Biol, 2010 Jun 4. PMID 20525357, Free PMC Article
  4. The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Epting D, et al. Circ Res, 2010 Jul 9. PMID 20466982
  5. Expression of unc5 family genes in zebrafish brain during embryonic development. Yang B, et al. Gene Expr Patterns, 2013 Dec. PMID 23806443

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.
    Title: A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.
  2. UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis.
    Title: The netrin receptor UNC5B promotes angiogenesis in specific vascular beds.
  3. A role of axon guidance genes in embryonic hindbrain patterning.
    Title: Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development.
  4. Disruption of the Unc5b or netrin-1a leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation
    Title: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
netrin receptor UNC5B
Names
unc-5 homolog B

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111149.1 → NP_001104619.1  netrin receptor UNC5B precursor

    See identical proteins and their annotated locations for NP_001104619.1

    Status: PROVISIONAL

    Source sequence(s)
    AY947468
    UniProtKB/TrEMBL
    A9JR35
    Related
    ENSDARP00000133154.1, ENSDART00000165544.3
    Conserved Domains (5) summary
    cd08802
    Location:853 → 936
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:252 → 303
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:158 → 246
    I-set; Immunoglobulin I-set domain
    pfam00791
    Location:538 → 632
    ZU5; ZU5 domain
    cl11960
    Location:160 → 246
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    32516448..32614543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307312.5 → XP_009305587.1  netrin receptor UNC5B isoform X1

    UniProtKB/TrEMBL
    A0A8M3AZ37, F1QXJ7
    Related
    ENSDARP00000102269.3
    Conserved Domains (5) summary
    cd08802
    Location:842 → 925
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:252 → 303
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:158 → 246
    I-set; Immunoglobulin I-set domain
    pfam00791
    Location:527 → 621
    ZU5; ZU5 domain
    cl11960
    Location:160 → 246
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.