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SPANXN2 SPANX family member N2 [ Homo sapiens (human) ]

Gene ID: 494119, updated on 6-Jul-2026
Official Symbol
SPANXN2provided by HGNC
Official Full Name
SPANX family member N2provided by HGNC
Primary source
HGNC:HGNC:33175
See related
Ensembl:ENSG00000268988 MIM:300665; AllianceGenome:HGNC:33175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT11.7; SPANX-N2
Expression
Restricted expression toward testis (RPKM 3.1) See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SPANXN2 in Genome Data Viewer
Location:
Xq27.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (143711955..143720752, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (142016971..142025768, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (142795055..142803846, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SLIT and NTRK like family member 4 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:142809175-142809676 Neighboring gene ubiquitin conjugating enzyme E2 N like (gene/pseudogene) Neighboring gene ribonucleotide reductase M2 polypeptide pseudogene 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. Westbrook VA, et al. Mol Hum Reprod, 2006 Nov. PMID 17012309
  2. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. Kouprina N, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14973187, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
sperm protein associated with the nucleus on the X chromosome N2
Names
cancer/testis antigen family 11, member 7
nuclear-associated protein SPAN-Xn2
NP_001009615.1

Length

  • 180

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009615.3 → NP_001009615.1  sperm protein associated with the nucleus on the X chromosome N2

    See identical proteins and their annotated locations for NP_001009615.1

    Status: VALIDATED

    Source sequence(s)
    AC239921, AL500522
    Consensus CDS
    CCDS35419.1
    UniProtKB/Swiss-Prot
    Q0ZNM2, Q5MJ10
    Related
    ENSP00000470584.1, ENST00000598475.2
    Conserved Domains (2) summary
    pfam06957
    Location:81 → 166
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    pfam07458
    Location:1 → 95
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    143711955..143720752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791819.1 Reference GRCh38.p14 PATCHES

    Range
    5667..5828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    142016971..142025768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MJ10.1 GenPept UniProtKB/Swiss-Prot:Q5MJ10

Gene LinkOut

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