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RBMXL1 RBMX like 1 [ Homo sapiens (human) ]

Gene ID: 494115, updated on 1-Jun-2020

Summary

Official Symbol
RBMXL1provided by HGNC
Official Full Name
RBMX like 1provided by HGNC
Primary source
HGNC:HGNC:25073
See related
Ensembl:ENSG00000213516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBM1
Summary
This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in ovary (RPKM 8.0), endometrium (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See RBMXL1 in Genome Data Viewer
Location:
1p22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (88979456..88992960, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89445139..89458643, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIB Neighboring gene shieldin complex subunit 1 pseudogene Neighboring gene kynurenine aminotransferase 3 Neighboring gene guanylate binding protein 3 Neighboring gene uncharacterized LOC105378841 Neighboring gene guanylate binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32614, DKFZp547N1117, DKFZp667D0223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of RNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA binding motif protein, X-linked-like-1
Names
RNA binding motif protein, X-linked like 1
heterogeneous nuclear ribonucleoprotein G-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162536.3NP_001156008.1  RNA binding motif protein, X-linked-like-1

    See identical proteins and their annotated locations for NP_001156008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL832785, BC012942, BF901720, DA216732
    Consensus CDS
    CCDS716.1
    UniProtKB/Swiss-Prot
    Q96E39
    Related
    ENSP00000498248.1, ENST00000652648.1
    Conserved Domains (3) summary
    COG0724
    Location:985
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family
  2. NM_019610.5NP_062556.2  RNA binding motif protein, X-linked-like-1

    See identical proteins and their annotated locations for NP_062556.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL832785, BC012942, BF901720, DC397531
    Consensus CDS
    CCDS716.1
    UniProtKB/Swiss-Prot
    Q96E39
    Related
    ENSP00000318415.5, ENST00000321792.5
    Conserved Domains (3) summary
    COG0724
    Location:985
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    88979456..88992960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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