ift27 intraflagellar transport 27 homolog (Chlamydomonas) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ift27provided by ZNC
Official Full Name: intraflagellar transport 27 homolog (Chlamydomonas)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-9
See related: Ensembl:ENSDARG00000099279 AllianceGenome:ZFIN:ZDB-GENE-041212-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rabl4; zgc:101893
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cilium assembly; kidney development; and regulation of melanosome transport. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi membrane and cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 19. Orthologous to human IFT27 (intraflagellar transport 27). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (489894..492318)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003334443.1 (11961..14356, complement)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFT27 regulates the long-term maintenance of photoreceptor outer segments in zebrafish.
Title: IFT27 regulates the long-term maintenance of photoreceptor outer segments in zebrafish.
Study coupled human genetics with functional validation in zebrafish and identified IFT27 as a novel BBS gene (BBS19).
Title: IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intraciliary transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intraflagellar transport protein 27 homolog

Names: RAB, member of RAS oncogene family-like 4

NP_001008588.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.