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APOB apolipoprotein B [ Bos taurus (domestic cattle) ]

Gene ID: 494004, updated on 30-Jan-2025
Official Symbol
APOBprovided by VGNC
Official Full Name
apolipoprotein Bprovided by VGNC
Primary source
VGNC:VGNC:26026
See related
BGD:BT13412; EnsemblRapid:ENSBTAG00070027479
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
APOB-100; ApoB(100)
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See APOB in Genome Data Viewer
Location:
chromosome: 11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (77885995..77927965)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene tudor domain containing 15 Neighboring gene uncharacterized LOC101902225 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene lactate dehydrogenase B pseudogene Neighboring gene lipid droplet associated hydrolase

Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study concludes that APOB-associated cholesterol deficiency represents most likely an incomplete dominant inherited metabolic disease with incomplete penetrance in heterozygotes.
    Title: APOB-associated cholesterol deficiency in Holstein cattle is not a simple recessive disease.
  2. The clinicopathological phenotype of affected Holstein cattle homozygous for the causative apolipoprotein B gene (APOB) mutation associated with cholesterol deficiency is described.
    Title: Clinicopathological Phenotype of Autosomal Recessive Cholesterol Deficiency in Holstein Cattle.
  3. Beyond malabsorption of dietary lipids, deleterious effects of apolipoprotein B deficiency on hepatic lipid metabolism, steroid biosynthesis, and cell membrane function can be expected, which may result in unspecific symptoms of reduced fertility, growth, and health.
    Title: Rapid Communication: Cholesterol deficiency-associated APOB mutation impacts lipid metabolism in Holstein calves and breeding bulls.
  4. Cholesterol deficiency results from a 1.3kbp insertion of an endogenous retrovirus (ERV2-1-LTR_BT) into exon 5 of the APOB gene at BTA11:77,959kb. The insertion is flanked by 6bp target site duplications as described for insertions mediated by retroviral integrases.
    Title: The Holstein Friesian Lethal Haplotype 5 (HH5) Results from a Complete Deletion of TBF1M and Cholesterol Deficiency (CDH) from an ERV-(LTR) Insertion into the Coding Region of APOB.
  5. A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
    Title: A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle.
  6. Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
    Title: Effects of nonesterified fatty acids on the synthesis and assembly of very low density lipoprotein in bovine hepatocytes in vitro.
  7. after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver.
    Title: Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cholesterol transfer activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipoprotein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in triglyceride mobilization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of mature chylomicron IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
apolipoprotein B-100

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    77885995..77927965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024999521.2 → XP_024855289.1  apolipoprotein B-100

    UniProtKB/TrEMBL
    A0AAA9S7B9, E1BNR0
    Related
    ENSBTAP00070037424.1, ENSBTAT00070062570.1
    Conserved Domains (6) summary
    pfam01347
    Location:43 → 594
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06448
    Location:957 → 1059
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:629 → 934
    DUF1943; Domain of unknown function (DUF1943)
    pfam12491
    Location:4496 → 4552
    ApoB100_C; Apolipoprotein B100 C terminal
    cl25729
    Location:2151 → 2385
    EzrA; Septation ring formation regulator, EzrA
    cl26203
    Location:4231 → 4418
    PolC; DNA polymerase III, alpha subunit (gram-positive type) [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version

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