MSH2 mutS homolog 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MSH2provided by VGNC
Official Full Name: mutS homolog 2provided by VGNC
Primary source: VGNC:VGNC:43438
See related: Ensembl:ENSCAFG00000002659
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (50390734..50467292)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (49372675..49449176)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (50572222..50649102)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (50098560..50174750)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (50386621..50461201)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	10	NC_006592.3 (49517448..49594001)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

EST18H1 (e-PCR)
- UniSTS:263181

GDB:549135 (e-PCR)
- UniSTS:157610

WI-18791 (e-PCR)
- UniSTS:28587

Homology

Homologs of the MSH2 gene: The MSH2 gene is conserved in human, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene MSH2
Orthologs

General protein information

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Preferred Names: DNA mismatch repair protein Msh2

Names: mutS homolog 2, colon cancer, nonpolyposis type 1; mutS-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051814.1 Reference ROS_Cfam_1.0

Range

50390734..50467292

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038680513.1 → XP_038536441.1 DNA mismatch repair protein Msh2

Alternate UMICH_Zoey_3.1

Genomic

NC_049270.1 Alternate UMICH_Zoey_3.1

Range

50098560..50174750

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038489230.1 → XP_038345158.1 DNA mismatch repair protein Msh2

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049751.1 Alternate UNSW_CanFamBas_1.0

Range

50386621..50461201

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038615130.1 → XP_038471058.1 DNA mismatch repair protein Msh2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049231.1 Alternate UU_Cfam_GSD_1.0

Range

50572222..50649102

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038551233.1 → XP_038407161.1 DNA mismatch repair protein Msh2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

49372675..49449176

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_538482.6 → XP_538482.2 DNA mismatch repair protein Msh2

UniProtKB/TrEMBL

F1PM37

Related

ENSCAFP00000003876.3

Conserved Domains (6) summary

cd03285
Location:633 → 852

ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog

COG0249
Location:23 → 853

MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

pfam01624
Location:18 → 132

MutS_I; MutS domain I

pfam05188
Location:158 → 284

MutS_II; MutS domain II

pfam05190
Location:473 → 569

MutS_IV; MutS family domain IV

pfam05192
Location:305 → 423

MutS_III; MutS domain III