PDX1 pancreatic and duodenal homeobox 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PDX1provided by VGNC
Official Full Name: pancreatic and duodenal homeobox 1provided by VGNC
Primary source: VGNC:VGNC:44396
See related: Ensembl:ENSCAFG00845025401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: IPF1; PDX-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	25	NC_051829.1 (11870873..11875895, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	25	NC_006607.4 (11805337..11810359, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	25	NC_049246.1 (11802135..11807157, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	25	NC_049285.1 (11765554..11770575, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	25	NC_049766.1 (11758195..11763217, complement)

Chromosome 25 - NC_051829.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results confirm that similar to humans, Pdx1 plays an important role in expression of insulin gene in canines.
Title: cDNA cloning and mRNA expression of canine pancreatic and duodenum homeobox 1 (Pdx-1).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in type B pancreatic cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pancreas/duodenum homeobox protein 1

Names: insulin promoter factor 1, homeodomain transcription factor; pancreatic and duodenum homeobox 1; pancreatic duodenal homeobox gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.