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GBE1 1,4-alpha-glucan branching enzyme 1 [ Felis catus (domestic cat) ]

Gene ID: 493962, updated on 10-Feb-2026
Official Symbol
GBE1
Official Full Name
1,4-alpha-glucan branching enzyme 1
Primary source
VGNC:VGNC:97178
See related
Ensembl:ENSFCTG00005001619
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
all
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Try the new Transcripts and proteins table
See GBE1 in Genome Data Viewer
Location:
chromosome: C2
Exon count:
19
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C2 NC_058376.1 (34520402..34811042, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C2 NC_018731.3 (34690586..34981283, complement)

Chromosome C2 - NC_058376.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109491696 Neighboring gene uncharacterized LOC109503381 Neighboring gene uncharacterized LOC102901880 Neighboring gene quinone oxidoreductase-like Neighboring gene tubulin beta-4B chain-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A complex rearrangement in GBE1 causes both perinatal hypoglycemic collapse and late-juvenile-onset neuromuscular degeneration in glycogen storage disease type IV of Norwegian forest cats. Fyfe JC, et al. Mol Genet Metab, 2007 Apr. PMID 17257876, Free PMC Article
  2. Sequencing and comparative genomic analysis of 1227 Felis catus cDNA sequences enriched for developmental, clinical and nutritional phenotypes. Irizarry KJ, et al. BMC Genomics, 2012 Jan 18. PMID 22257742, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The rearrangement in GBE1 segregates with the disease in the GSD IV kindred and is not found in unrelated normal cats.
    Title: A complex rearrangement in GBE1 causes both perinatal hypoglycemic collapse and late-juvenile-onset neuromuscular degeneration in glycogen storage disease type IV of Norwegian forest cats.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1,4-alpha-glucan branching enzyme activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cation binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
1,4-alpha-glucan-branching enzyme
Names
brancher enzyme
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)
glycogen branching enzyme
NP_001009872.1
XP_019694798.1
XP_044892258.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009872.1 → NP_001009872.1  1,4-alpha-glucan-branching enzyme

    See identical proteins and their annotated locations for NP_001009872.1

    Status: PROVISIONAL

    Source sequence(s)
    AY439007
    UniProtKB/Swiss-Prot
    Q6T308
    UniProtKB/TrEMBL
    A0ABI7VWZ3
    Related
    ENSFCTP00005002512.1, ENSFCTT00005004197.1
    Conserved Domains (4) summary
    cd02854
    Location:80 → 175
    E_set_GBE_euk_N; N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme)
    cd11321
    Location:177 → 582
    AmyAc_bac_euk_BE; Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes
    COG0296
    Location:70 → 692
    GlgB; 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]
    pfam02806
    Location:600 → 695
    Alpha-amylase_C; Alpha amylase, C-terminal all-beta domain

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058376.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    34520402..34811042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019839239.3 → XP_019694798.1  1,4-alpha-glucan-branching enzyme isoform X1

    UniProtKB/TrEMBL
    A0ABI7VWM7, A0ABI7VWZ3
    Related
    ENSFCTP00005002514.1, ENSFCTT00005004199.1
    Conserved Domains (1) summary
    cl25948
    Location:27 → 682
    PulA; Pullulanase/glycogen debranching enzyme [Carbohydrate transport and metabolism]

  2. XM_045036323.1 → XP_044892258.1  1,4-alpha-glucan-branching enzyme isoform X2

    UniProtKB/TrEMBL
    A0ABI7VWF5, A0ABI7VZU4
    Related
    ENSFCTP00005002490.1, ENSFCTT00005004176.1
    Conserved Domains (1) summary
    PLN02447
    Location:27 → 642
    PLN02447; 1,4-alpha-glucan-branching enzyme

RNA

  1. XR_002162120.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6T308.1 GenPept UniProtKB/Swiss-Prot:Q6T308

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials